含燕麦仁油的舒缓护理霜改善儿童干皮症及角质层含水量的研究  

Improvement of xeroderma and water content of the stratum corneum in children with a moisturizer con-taining oat kernel oil

作　　者：吴素华 周可飞 李明 姜景新 张铱祯 李妍[1] 李邻峰[1] Wu Suhua;Zhou Kefei;Li Ming;Jiang Jingxin;Zhang Yizhen;Li Yan;Li Linfeng(Department of Dermatology and Venereology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Department of Dermatology,Tongzhou Maternal and Child HealthHospital,Beijing 101100,China)

机构地区：[1]首都医科大学附属北京友谊医院皮肤性病科,北京100050 [2]北京市通州区妇幼保健院皮肤科,北京101100

出　　处：《中华医学美学美容杂志》2023年第3期218-222,共5页Chinese Journal of Medical Aesthetics and Cosmetology

基　　金：中国老年保健医学研究会科研课题(Z2022020803)。

摘　　要：目的评估一种富含燕麦仁油的舒缓护理霜对儿童干皮症及角质层含水量的影响。方法2022年9-12月,北京市通州区妇幼保健院皮肤科就诊的干皮症患儿30例,男13例、女17例,年龄3~12(7.3±2.6)岁。患儿双侧肢体用单中心自身前后对照方法,在皮肤干燥处用舒缓护理霜,每日2次,共14d。分别在使用后7d及14d随访,检测皮肤角质层含水量、简易视觉评分、干燥严重程度量表(XSS)、特定症状总评分(SRRC)、患儿瘙痒视觉模拟评分(VAS)评估舒缓护理霜的效果,记录不良反应。结果干皮症患儿用舒缓护理霜7d和14d后,角质层含水量中位数分别为49.00(33.83,87.25)、48.84(32.58,100.34);较基线[26.51(16.00,47.75)]明显升高,差异均有统计学意义(Z=-3.075、-2.911,均P<0.01)。简易视觉评分、XSS评分、SRRC评分、VAS评分与基线相比,均显示皮肤干燥、瘙痒评分有改善,差异均有统计学意义(7d:Z=-4.424、-4.150、-3.943、4.400,14d:Z=-4.744、-4.409、4.260、-4.409,均P<0.01)。结论富含燕麦仁油的舒缓护理霜对儿童皮肤干燥及皮肤角质层含水量有明显改善作用,无不良反应。Objective To evaluate the influence of a moisturizer containing oat kernel oil for xe-roderma and water content of the stratum corneum in children.Methods From September to Decem-ber 2022,30 children with xeroderma were treated in the Dermatology Department of Tongzhou Ma-ternal and Child Health Hospital of Beijing;13 were males and 17 were females,and the age was 7.33±2.63 years.This was a single-center self-controlled trial.All children applied the moisturizer on the dry skin of the bilateral limbs two time per day for l4 days,and were followed up at 7 days and 14 days.Efficacy was evaluated according to the water content of the stratum corneum,visual scale,xerosis severity scale(XSS),Specified Symptom Sum Score(SRRC),Visual Analog Scale(VAS)and so on.and side-reactions were recorded.Results After application of the moisturizer,the medi-an of water content in the stratum corneum was 49.00(33.83,87.25),48.84(32.58,100.34)at 7 d and 14 d respectively,showing significant increases compared with that at baseline(median 26.51)(16.00,47.75)(Z=-3.075,Z=-2.911,P<0.01).The visual scale,XSS,SRRCand VAS showed that compared with the baseline at 7 d,14 d,the skin dryness and pruritus scores improved significantly(Z=-4.424,-4.150,-3.943,-4.400;Z=-4.744,-4.409,-4.260,-4.409,P<0.01).Conclusions The application of this moisturizer containing oat kernel oil could effectively improve skin dryness and the water content of the stratum corneum without serious adverse reactions.

关 键 词：干皮症 皮肤干燥 燕麦仁油 保湿剂 儿童 

分 类 号：R473.75[医药卫生—护理学]