A型肉毒毒素治疗手部多汗症的效果  

Clinical efficacy of botulinum toxin A in the treatment of hand hyperhidrosis

作　　者：雷旭光 戴骊颖 于炳洋 陈星星 Lei Xuguang;Dai Liying;Yu Bingyang;Chen Xingxing(Department of Medical Cosmetology,Weihai Municipal Hospital Affiliated to Shandong Universi-ty,Weihai 264200,China)

机构地区：[1]山东大学附属威海市立医院医疗美容科,威海264200

出　　处：《中华医学美学美容杂志》2023年第3期227-230,共4页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的探讨A型肉毒毒素治疗手部多汗症的效果。方法2016年8月至2020年10月,威海市立医院医疗美容科就诊手部多汗症患者100例,男45例、女55例,年龄16~35(26±4.8)岁,病程5~20年。均用A型肉毒毒素注射治疗,共200U,每只手分别注射100U。对有效率,满意度,不良反应进行评估评估。结果与治疗前比较,注射2周,注射1、4、6个月后手部多汗症患者的有效率比较,差异均有统计学意义(χ^(2)=31.54、36.33、28.34、25.23,均P<0.05)。经过6个月随访后效果慢慢减退,效果维持可达10个月,复发后手汗症状较前减轻。患者满意度96.0%(96/100);不良反应仅为皮下瘀血,27例(27.0%)手部肌肉轻微无力,2~3周后恢复正常。结论注射A型肉毒毒素治疗手部多汗症效果肯定、安全性高、不良反应少,是治疗手部多汗症理想方法。Objective To investigate the clinical efficacy of botulinum toxin A in the treatment of hand hyperhidrosis.Methods One hundred patients with hand hyperhidrosis were treated with botulinum toxin A(BTXA,Lanzhou Biotechnology Development Co.,Ltd.,Botulinum Toxin Type A for Injection Hengli)injection,a total of 200 U.Each hand was injected with 100 U respectively.The curative effect was evaluated by self-made questionnaire.The scores of the two were added.The subjective and objective evaluation were carried out before and after injection,and the patients were re-checked 2 weeks,and 1,4 and 6 months after injection.Efficacy,patient satisfaction and adverse re-actions were evaluated.Results Compared with before treatment,the effective rate increased 2 weeks after injection,1 month after injection,4 months after injection and 6 months after injection,and the difference was statistically significant(Chi-square value was 31.54,36.33,28.34,25.23,respectively,P<0.05).After 6 months of follow-up,the effect gradually decreased,and the curative effect could be maintained for about 1o months.After recurrence,the symptoms of hand sweating were still reduced.Satisfaction 96%;Adverse reactions were mild,subcutaneous blood stasis,27%hand muscles were slightly weak,and returned to normal after 2-3 weeks.Conclusions Botulinum toxin A injection has certain curative effect,high safety and less adverse reactions.It is an ideal meth-od for the treatment of hand hyperhidrosis.

关 键 词：多汗症 A型肉毒毒素 手部 注射 效果 

分 类 号：R758.743[医药卫生—皮肤病学与性病学]