割舌树中的两个新四降三萜walsurobustones F和G  

Walsurobustones F and G:Two New Tetranortriterpenoids from Walsura robusta

作　　者：侯丽[1,2,3] 曹明明 赵庆[2] 何红平 郝小江 HOU Li;CAO Mingming;ZHAO Qing;HE Hongping;HAO Xiaojiang(State Key Laboratory of Photochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China;Yunnan University of Chinese Medicine,Kunming 650500,China;Bureau of Commerce and Market Supervision of Management Committee of Hunan Xiangjiang New Area,Changsha 410205,China)

机构地区：[1]中国科学院昆明植物研究所,植物化学与西部植物资源持续利用国家重点实验室,云南昆明650201 [2]云南中医药大学,云南昆明650500 [3]湖南湘江新区管委会商务和市场监管局,湖南长沙410205

出　　处：《云南中医药大学学报》2023年第3期95-98,共4页Journal of Yunnan University of Chinese Medicine

基　　金：云南特色植物筛选与研发服务CXO平台建设(2022YKZY001)。

摘　　要：四降三萜是众多芸香科及楝科中药材中的细胞毒活性成分,其化学结构上碳骨架多变、高度氧化。本文报道从割舌树叶片中分离得到了两个新的四降三萜类化合物,被命名为walsurobustones F(1)和G(2)。它们的结构通过一维与二维核磁,及质谱数据进行了解析。从结构上看,1和2是一对C-22位的差向异构体。细胞毒测试显示1和2对人肿瘤细胞株HL-60、SMMC-7721、A-549、MCF-7和SW480表现出了显著的细胞毒活性。Tetranortriterpenoids are the major secondary metabolites in traditional Chinese medicine from family Meliaceae and Rutaceae,which structurally featured by diverse carbon skeletons and highly oxidized degree.Two new tetranortriterpenoids,walsurobustones F(1)and G(2),were isolated from the leaves of Walsura robusta.Their structures were elucidated by 1D NMR,2D NMR,and MS spectra.Structurally,1 and 2 are two geometric isomers that differ at position C-22.Both 1 and 2 showed obvious antitumor activity against the cancer cell lines HL-60,SMMC-7721,A-549,MCF-7,and SW480.These findings suggest that walsurobustones F(1)and G(2)have the potential to be used as anti-cancer agents.

关 键 词：割舌树 柠檬苦素 四降三萜 细胞毒 

分 类 号：R284.1[医药卫生—中药学] R285.5[医药卫生—中医学]