NSP16 promotes the expression of TMPRSS2 to enhance SARS-CoV-2 cell entry  

作　　者：Tianyu Han Jiapeng Lei Yang Liu Yanan Wang Wenze Xun Qifan Hu Qi Peng Wei Zhang 

机构地区：[1]Jiangxi Institute of Respiratory Disease,The First Affiliated Hospital of Nanchang University,Nanchang,Jiangxi 330006,China [2]Jiangxi Clinical Research Center for Respiratory Diseases,Nanchang,Jiangxi 330006,China [3]Jiangxi Hospital of China-Japan Friendship Hospital,Nanchang,Jiangxi 330052,China [4]Department of Bacteriology,The First Affiliated Hospital of Nanchang University,Nanchang,Jiangxi 330006,China

出　　处：《Genes & Diseases》2023年第3期723-726,共4页基因与疾病（英文）

基　　金：supported by Clinical Research Cultivation Project of First Affiliated Hospital of Nanchang University(China)(No.YFYLCYJPY202001).

摘　　要：Since the end of 2019,COVID-19 has caused worldwide pandemic.SARS-CoV-2,the culprit of this epidemic,binds to the host receptor Angiotensin converting enzyme 2(ACE2)using spike(S)protein for cell entry.Recent studies showed that ACE2 expressed at a low level in the main target organs such as lung and bronchial tissues.How SARS-CoV-2 efficiently invades into the respiratory system or other organs with low levels of ACE2 is an urgent problem to be solved.

关 键 词：ACE2 NSP1 ORGANS 

分 类 号：R563.1[医药卫生—呼吸系统]