硼碳氮纳米管的制备及靶向递送阿霉素的抗肿瘤性能  

Preparation of boron carbonitride nanotubes using as targeted delivery vehicle for DOX and the antitumor performance

作　　者：杨欢 李佳鑫 顾水丹 骆丽杰[1] 陈拥军[1] YANG Huan;LI Jiaxin;GU Shuidan;LUO Lijie;CHEN Yongjun(School of Materials Science and Engineering,Hainan University,Haikou 570228,Hainan,China;School of Materials Science and Engineering,Huazhong University of Science and Technology,Wuhan 430074,Hubei,China)

机构地区：[1]海南大学材料科学与工程学院,海南海口570228 [2]华中科技大学材料科学与工程学院,湖北武汉430074

出　　处：《精细化工》2023年第6期1294-1301,共8页Fine Chemicals

基　　金：海南省基础与应用基础研究计划(自然科学领域)高层次人才项目(2019RC029)。

摘　　要：通过改进固相合成法制备了硼碳氮纳米管(BCNNTs),并利用XRD、FTIR和SEM对其进行了表征。然后,采用叶酸(FA)对BCNNTs进行功能化修饰,用于负载阿霉素(DOX),构建了FA-BCNNTs-DOX靶向给药系统,并评价了该载药系统的抗肿瘤效果。结果表明,DOX有效负载到BCNNTs和FA-BCNNTs上,其负载量分别为67.33和87.11mg/g。与DOX和BCNNTs-DOX相比,FA-BCNNTs-DOX能引起更多的人乳腺癌MDA-MB-231细胞死亡,这归因于在叶酸受体介导的内吞作用下,MDA-MB-231细胞对FA-BCNNTs-DOX的摄取能力得到明显提高。在肿瘤细胞酸性条件下,FA-BCNNTs-DOX释放DOX,DOX在细胞核内逐步积累,从而产生优异的抗肿瘤效果。Boron carbonitride nanotubes(BCNNTs)were prepared via an improved solid-state synthesis method and characterized by XRD,FTIR and SEM.Then the targeted drug delivery system of FA-BCNNTs-DOX was constructed by loading doxorubicin(DOX)into folate(FA)functionalized BCNNTs,and analyzed for its anti-tumor performance.The results showed that DOX was successfully encapsulated into BCNNTs and FA-BCNNTs with a loading capacity of 67.33 and 87.11 mg/g,respectively.Compared with DOX and BCNNTs-DOX,FA-BCNNTs-DOX led to more significant human breast cancer MDA-MB-231 cells growth inhibition,which was attributed to the enhanced FA-BCNNTs-DOX uptake capacity of MDA-MB-231 cells via folate receptor-mediated endocytosis.Under the acidic environment of tumor cells,DOX was released from FA-BCNNTs-DOX,and gradually accumulated in the nucleus,thus producing excellent anti-tumor effects.

关 键 词：硼碳氮纳米管 阿霉素 叶酸 靶向递送 抗肿瘤 功能材料 

分 类 号：TQ460.4[化学工程—制药化工] TB34[一般工业技术—材料科学与工程]