外周性性早熟病因及诊治新进展  

Further progress of the etiology,diagnosis and treatment of peripheral precocious puberty

作　　者：张金[1] 万乃君[1] Zhang Jin;Wan Naijun(Department of Pediatrics,Beijing Jishuitan Hospital,Beijing 100035,China)

机构地区：[1]北京积水潭医院儿科,北京100035

出　　处：《中华预防医学杂志》2023年第6期955-960,共6页Chinese Journal of Preventive Medicine

基　　金：吴阶平医学基金会临床科研专项资助基金经费资助(320.6750.2020-06-86)

摘　　要：外周性性早熟又称非促性腺激素释放激素依赖性性早熟,指非下丘脑-垂体-性腺轴激活,而是由其他来源的激素刺激引起的男孩在9岁前、女孩在7.5岁前出现第二性征发育,但不具备完整的性发育过程,仅有部分性征发育。外周性性早熟临床表现多样,常见的病因包括先天性肾上腺皮质增生症、McCune-Albright综合征、卵巢囊肿、肾上腺肿瘤、卵巢肿瘤、睾丸肿瘤、分泌人绒毛膜促性腺激素肿瘤、家族性男性性早熟、家族性芳香化酶活性增高及环境雌激素等。早期识别病因、精准鉴别诊断、产前基因筛查对该病的预防及诊治具有非常重要的意义。Peripheral precocious puberty(PPP),also known as puberty independent from hypothalamic-pituitary axis activation,is stimulated by hormones from other sources,with only partial sexual characteristics development but without mature sexual function.The secondary sexual characteristics development occurs before 7.5 years of age in girls and before 9 years of age in boys.Clinical manifestations are diverse,and PPP has varied etiology including congenital adrenal hyperplasia,McCune-Albright syndrome,ovarian cyst,adrenal tumor,ovarian tumor,testicular tumor,human chorionic gonadotropin producing tumor,familial male precocious puberty,aromatase excess syndrome,and environmental estrogen.Early identification of etiology,accurate differential diagnosis and prenatal gene screening play a significant role in the prevention,diagnosis and treatment of the disease.

关 键 词：性早熟 外周性 病因 儿童 

分 类 号：R725.8[医药卫生—儿科]