基于选择性激光熔化技术的骨缺损修复用梯度多孔钛支架的研制与表征  

Development and characterizations of graded porous titanium scaffolds via selective laser melting for orthopedics applications

作　　者：于爱华 徐伟 路新[1,2,3] Maryam TAMADDON 刘博文[1] 田世伟 张策 Muhammad Arif MUGHAL 张嘉振 Chao-zong LIU Ai-hua YU;Wei XU;Xin LU;Maryam TAMADDON;Bo-wen LIU;Shi-wei TIAN;Ce ZHANG;Muhammad Arif MUGHAL;Jia-zhen ZHANG;Chao-zong LIU(National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing,Institute of Engineering Technology,University of Science and Technology Beijing,Beijing 100083,China;Shunde Innovation School,University of Science and Technology Beijing,Foshan 528399,China;Beijing Advanced Innovation Center for Materials Genome Engineering,State Key Laboratory for Advanced Metals and Materials,University of Science and Technology Beijing,Beijing 100083,China;Institute of Orthopaedic&Musculoskeletal Science,University College London,Royal National Orthopaedic Hospital,Stanmore HA74LP,UK;National Engineering Technology Research Center of Flat Rolling Equipment,Institute of Engineering Technology,University of Science and Technology Beijing,Beijing 100083,China;Institute of Artificial Intelligence,University of Science and Technology Beijing,Beijing 100083,China)

机构地区：[1]北京科技大学工程技术研究院高效轧制与智能制造国家工程研究中心,北京100083 [2]北京科技大学顺德创新学院,佛山528399 [3]北京科技大学新金属材料国家重点实验室北京材料基因工程高精尖创新中心,北京100083 [4]Institute of Orthopaedic&Musculoskeletal Science,University College London,Royal National Orthopaedic Hospital,Stanmore HA74LP,UK [5]北京科技大学工程技术研究院国家板带生产先进装备工程技术研究中心,北京100083 [6]北京科技大学人工智能研究院,北京100083

出　　处：《Transactions of Nonferrous Metals Society of China》2023年第6期1755-1767,共13页中国有色金属学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.51922004,51874037);State Key Lab of Advanced Metals and Materials,University of Science and Technology Beijing,China(Nos.2019Z-14,2020Z-04,2021Z-03);Fundamental Research Funds for the Central Universities,China(Nos.FRF-TP-19005C1Z,06500236);Interdisciplinary Research Project for Young Teachers of USTB,China(Fundamental Research Funds for the Central Universities,FRF-IDRY-20-023);Postdoctor Research Foundation of Shunde Graduate School of University of Science and Technology Beijing,China(No.2022BH001);the China Postdoctoral Science Foundation(No.2021M700377);the Beijing Natural Science Foundation,China(No.2212035);the support from the European Commission via the H2020 MSCA RISE BAMOS program(No.734156);Innovate UK via Newton Fund(No.102872);Engineering and Physical Science Research Council(EPSRC)via DTP case programme(No.EP/T517793/1)。

摘　　要：为提高骨缺损修复的治疗效果,设计孔隙率为78.8%、70.8%、62.6%和54.4%的梯度多孔钛支架(分别表示为P1,P2,P3和P4),并通过选择性激光熔化技术进行制备。通过模拟和实验方法研究支架的成形性、显微组织、力学性能和渗透性能。模拟结果表明,4种梯度结构的最大等效应力和渗透性分别在569.1~1469.0MPa和(21.7~54.6)×10^(−9)m^(2)范围内,并且P3和P4具有更小的最大等效应力,表明P3和P4具有更高的强度。P3和P4结构支架的显微组织为α'马氏体,屈服强度和弹性模量分别为185.3~250.8MPa和6.1~9.7GPa。相比于P3结构支架,P4结构支架展现出更高的强度和与皮质骨更加匹配的弹性模量,并且其渗透性(18.6×10^(−9)m^(2))在人体骨组织渗透性范围内。因此,具有P4结构支架有望被应用于骨科植入领域。To improve the treatment effect of bone defect repair,titanium scaffolds having graded structures with porosities of 78.8%,70.8%,62.6%,and 54.4%(denoted as P1,P2,P3,and P4,respectively)were designed and fabricated by selective laser melting.The manufacturability,microstructure,mechanical properties,and permeability were investigated theoretically and experimentally.Simulation results showed that the maximum von Mises stress and permeability were in the range of 569.1−1469.0 MPa and(21.7−54.6)×10^(−9)m^(2)respectively.Thereinto,P3 and P4 exhibited lower maximum von Mises stress,meaning a higher strength.The microstructure of fabricated scaffolds with P3 and P4 consisted of martensiticα'phase.The yield strength and elastic modulus were 185.3−250.8 MPa and 6.1−9.7 GPa,respectively.Compared with the scaffold with P3,the scaffold with P4 exhibited higher yield strength and a more matched elastic modulus to cortical bone,and its permeability(18.6×10^(−9)m^(2))was within the range of permeability of human bone.Comprehensively,the scaffold with P4 is a promising candidate for bone defect reconstructions.

关 键 词：梯度多孔钛 骨植入体 选择性激光熔化 力学性能 渗透性 

分 类 号：R318.08[医药卫生—生物医学工程] TG665[医药卫生—基础医学]