2-羟基-4-甲氧基苯乙酮在有机合成中的应用  

Application of 2-hydroxy-4-methoxyacetophenone in Organic Synthesis

作　　者：安超娜 王乙颖 刘存芳[1] 任传清[1] 张强[1] 田光辉[1] AN Chaona;WANG Yiying;LIU Cunfang;REN Chuanqing;ZHANG Qiang;TIAN Guanghui(Shaanxi Key Laboratory of Catalysis,Shaanxi University of Technology,Shaanxi Hanzhong 723000,China)

机构地区：[1]陕西理工大学陕西省催化基础与应用重点实验室,陕西汉中723000

出　　处：《河北师范大学学报（自然科学版）》2023年第4期380-393,共14页Journal of Hebei Normal University：Natural Science

基　　金：陕西省科技厅社会发展科技攻关项目(2022SF-356,2021SF-382);陕西省教育厅科研项目(21JK0569,21JS003);陕西理工大学2022年研究生创新基金(SLGYCX2227)。

摘　　要：2-羟基-4-甲氧基苯乙酮(丹皮酚),因其特殊的结构而具有显著的药理活性,常被作为先导物用于构建多种衍生物.综述了在丹皮酚中的羰基、酚羟基、乙酰基中的α甲基、苯环等活性位点上进行反应来制备丹皮酚衍生物,重点讨论了丹皮酚衍生物的合成过程和产物种类,简单论述了其药理活性,以期为丹皮酚在有机合成中的精细化深加工应用提供参考.2-hydroxy-4-methoxyacetophenone(Paeonol)with unique structure and significant pharmacological activity is often used as a lead in the construction of various derivatives.This article reviewed the preparation of Paeonol derivatives by reactions on active site such as carbonyl,phenolic hydroxyl,αmethyl of the acetyl,and benzene ring in the Paeonol,etc.The synthesis process and product types of Paeonol derivatives were emphatically discussed,and their pharmacological activities were briefly discu-ssed.The work provided references for the fine and deep processing and application of Paeonol in organic synthesis.

关 键 词：2-羟基-4-甲氧基苯乙酮 合成 衍生物 中间体 

分 类 号：Q938.3[生物学—微生物学]