CAR-T细胞椎管内注射治疗复发胶质瘤患者的护理  

Nursing care of patients with recurrent glioblastoma treated with intraspinal injection of CAR-T cells

作　　者：张娜[1] 陈延明[1] Zhang Na;Chen Yanming(Neurosurgery Department of the Second Affiliated Hospital of Soochow University,Suzhou 215000,China)

机构地区：[1]苏州大学附属第二医院神经外科,江苏苏州215000

出　　处：《护理学杂志》2023年第12期39-42,共4页Journal of Nursing Science

基　　金：国家自然科学基金资助项目(81602183)。

摘　　要：对8例复发胶质瘤患者行CAR-T细胞椎管内注射治疗。在常规护理的基础上密切观察和积极救治细胞因子释放综合征及中枢神经系统毒性反应,精心护理皮肤损害,细化腰大池置管护理和心理支持。结果8例患者顺利完成疗程,治疗相关并发症得到有效控制;5例病情好转出院,3例病情进展(2例出院,1例再次手术)。个体化精细护理有助于患者顺利完成治疗。Eight patients with recurrent glioblastoma were treated with intraspinal injection of chimeric antigen receptor(CAR)T cells.We provided not only routine nursing care but also intensive monitoring of cytokine release syndrome and neurotoxicity,care of skin damage,care of the lumbar cistern catheter and psychological support.All patients successfully completed the treatment,and their treatment-related complications were effectively controlled.Five patients were discharged with improvement and 3 progressed(of whom 2 were discharged and 1 had a second operation).It is suggested that individualized nursing care is helpful to patients to successfully complete the treatment.

关 键 词：复发胶质瘤 嵌合抗原受体T细胞技术 椎管内注射 护理 

分 类 号：R473.6[医药卫生—护理学]