耐甲氧西林金黄色葡萄球菌感染新型控制策略研究新进展  

New progress in research on novel control strategies for methicillinresistant staphylococcus aureus infection

作　　者：乔红亮 丁宁 邓凯红 刘彬彬[1,2] 董传江 陈晓波[1] 邹黎黎[2,3] QIAO Hongliang;DING Ning;DENG Kaihong;LIU Binbin;DONG Chuanjiang;CHEN Xiaobo;ZOU Lili(The First College of Clinical Medical Science,China Three Gorges University,Yichang 443000,Hubei,China;Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy;The Institute of Infection and Inflammation,College of Basic Medical Sciences,China Three Gorges University,Yichang 443000,Hubei,China;School of Pharmacy,Hubei University of Science and Technology,Xianning 437100,Hubei,China)

机构地区：[1]三峡大学第一临床医学院,湖北宜昌443000 [2]肿瘤微环境与免疫治疗湖北省重点实验室,湖北宜昌443000 [3]感染与炎症损伤研究所,三峡大学基础医学院,湖北宜昌443000 [4]湖北科技学院药学院,湖北咸宁437100

出　　处：《中国临床药理学与治疗学》2023年第6期676-687,共12页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金(32170191)。

摘　　要：耐甲氧西林金黄色葡萄球菌(methicillin-resistant staphylococcus aureus,MRSA)是临床常见的多重耐药菌之一,被称为“超级细菌”。随着MRSA耐药机制的不断进化,通过传统抗生素治疗MRSA感染的困难不断增加。近年来,针对MRSA感染的新型控制策略从各个层面不断深入。纳米材料的独特结构具有抗菌活性,也可作为一种高效的抗菌药物输送载体。光动力疗法通过光激活光敏剂(photosensitizer,PS)与分子氧或底物作用产生活性氧(reactive oxygen species,ROS)促进细胞氧化应激。中草药多种机制的抗菌特性已经被广泛证实。免疫疗法在对抗MRSA的免疫逃逸机制、多价疫苗和混合抗体的使用取得了突破。以mecA基因为代表的基因靶点正在不断被发掘。靶向硫醇依赖的氧化还原系统(thiol-dependent redox system,TDRS)尤其是硫氧还蛋白系统(thioredoxin system,Trx system)的新型候选抗菌化合物将是未来充满潜力的生力军。本文将MRSA的新型控制策略进行综述和展望。Methicillin-resistant staphylococcus aureus(MRSA)is one of the most common multidrug resistant bacteria in clinical practice and is known as a"superbug".With the evolution of MRSA resistance mechanisms,it is increasingly difficult to treat MRSA infections with conventional antibiotics.In recent years,novel control strategies for MRSA infections have been developed at various levels.The unique structure of nanomaterials has antimicrobial activity and can also be used as an efficient transport carrier.Photodynamic therapy promotes cellular oxidative stress by light-activated photosensitizer(PS)interacting with molecular oxygen or substrates to generate reactive oxygen species(ROS).The antimicrobial properties of herbal medicines by multiple mechanisms have been widely demonstrated.Immunotherapy has made breakthroughs in the use of immune escape mechanisms,polyvalent vaccines,and mixed antibodies against MRSA.Gene targets represented by the mecA gene are being explored.Novel candidate antibacterial compounds targeting TDRS,especially the Trx system,will be a promising force in the future.In this paper,novel control strategies for MRSA are reviewed and prospected.

关 键 词：耐甲氧西林金黄色葡萄球菌 纳米技术 光动力疗法 中药疗法 免疫疗法 基因策略 新型候选抗菌化合物 

分 类 号：R378.1[医药卫生—病原生物学]