PCSK9对血管内皮功能影响的研究进展  

Effects of PCSK9 on Vascular Endothelial Function

作　　者：许晓宇 唐炯 郑甲林[1] XU Xiaoyu;TANG Jiong;ZHENG Jialin(The Affiliated Cardiovascular Hospital of Kunming Medical University(Fuwai Yunnan Cardiovascular Hospital),Kunming 650000,Yunnan,China)

机构地区：[1]昆明医科大学附属心血管病医院(云南省阜外心血管病医院),云南昆明650000

出　　处：《心血管病学进展》2023年第6期551-556,共6页Advances in Cardiovascular Diseases

基　　金：云南省心血管病临床医学中心项目(FZX2019-06-01);云南省心血管系统疾病临床医学研究中心-重大心血管疾病诊治新技术研发项目(202102AA310002)。

摘　　要：血脂异常是心血管疾病最重要的危险因素之一。前蛋白转化酶枯草溶菌素9(PCSK9)在胆固醇代谢中起着重要作用,是胆固醇稳态诱导的低密度脂蛋白受体降解的关键调节因子。降低胆固醇水平可能会改善冠状动脉内皮功能,其表达水平升高可能与心血管风险增加有关,抑制PCSK9的抗体可能会降低冠状动脉疾病患者的心血管事件发生率。现就PCSK9对血管内皮功能影响的研究进展做一综述。Dyslipidemia is one of the most important risk factors for cardiovascular disease.The proprotein convertase subtilisin/kexin type 9(PCSK9)plays an important role in cholesterol metabolism and is a key regulator of low-density lipoprotein receptor degradation induced by cholesterol homeostasis.Lowering cholesterol levels may improve coronary artery endothelial function,elevated levels of its expression may be associated with increased cardiovascular risk,and antibodies that inhibit it may reduce the incidence of cardiovascular events in patients with coronary artery disease.This article reviews the research progress on the effects of PCSK9 on vascular endothelial function.

关 键 词：前蛋白转化酶枯草溶菌素9 前蛋白转化酶枯草溶菌素9抑制剂 血管内皮功能 动脉粥样硬化 

分 类 号：R54[医药卫生—心血管疾病]