基于COMSOL的多层组织声光作用机制  

Acousto-Optical Interaction Mechanism of Multilayer Tissue Based on COMSOL

作　　者：邓辉煌 刘遥 宋海洋 朱莉莉 Deng Huihuang;Liu Yao;Song Haiyang;Zhu Lili(Fujian Provincial Key Laboratory of Photonics Technology,Key Laboratory of Opto-Electronic Science and Technology for Medicine of Ministry of Education,College of Photonic and Electronic Engineering,Fujian Normal University,Fuzhou 350007,Fujian,China)

机构地区：[1]福建师范大学光电与信息工程学院,医学光电科学与技术教育部重点实验室,福建省光子技术重点实验室,福建福州350007

出　　处：《光学学报》2023年第10期203-213,共11页Acta Optica Sinica

基　　金：国家自然科学基金青年科学基金(11804051);福建省自然科学基金(2017J01742)。

摘　　要：采用COMSOL Multiphysics软件对不同结构组织中的声光作用过程进行仿真,讨论轴向和径向的光分布特点以及单层和多层组织光学参数对声光信号的影响。仿真结果表明:入射光束的大小对轴向和径向光的衰减速度以及轴向能流率峰值出现位置均产生影响;声光信号的峰峰值、平均值以及调制深度均随单层组织光学特性的改变而规律性变化;对于多层结构,声光信号的调制深度仅取决于靶组织的光学特性,与非靶组织的光学特性无关。Objective The optical parameters and structural characteristics of biological tissue are an important basis for medical clinical diagnosis.Biomedical optical imaging technology has gradually become a new pioneering field developing rapidly in the international arena due to its advantages of safety,non-destructive characteristics,high detection sensitivity,and realization of functional imaging in tissue.However,pure optical imaging techniques such as optical coherence tomography and diffusion optical tomography are unable to obtain excellent imaging resolution and large imaging depth at the same time.Therefore,acousto-optical tomography(AOT)which is a hybrid imaging method emerges.It can offer a great spatial resolution of imaging(sub-millimeter level)in deeper tissue(centimeter-level)because the ultrasound has low scattering in tissue to locate the scattered light.Therefore,it is a promising non-destructive imaging technology for biological tissue.However,the research process of AOT faces two main problems,including the research on acoustooptical interaction mechanisms in tissue and the extraction of weak modulated light signals in strong background light.In this paper,COMSOL Multiphysics software is used to simulate the acousto-optical interaction process in various structural tissue.It is a new approach to studying the acousto-optical interaction mechanism.The simulation results can provide an important basis for data analysis and final image processing and reconstruction by AOT.Methods The acousto-optical interaction mechanism can be divided into coherent modulation mechanism and incoherent modulation mechanism in terms of the choice of light sources and the modulation effect of ultrasound.The incoherent modulation mechanism mainly refers to the change in light energy caused by the periodic change in optical parameters(including absorption coefficient,scattering coefficient,and refractive index)of tissue under the effect of an ultrasonic field.It does not require coherent light as the light source,so it belong

关 键 词：生物光学 声光作用机制 光学参数 多层组织 调制深度 

分 类 号：Q631[生物学—生物物理学]