Alkyl-modified nucleobases with 6/5/7/5 ring systems from the insect Cyclopelta parva  

作　　者：Yong-Ming Yan Heng Chen Wen-Long Chen Dai-Wei Wang Li Liao Qing Lu Yong-Xian Cheng 

机构地区：[1]Institute for Inheritance-Based Innovation of Chinese Medicine,Marshall Laboratory of Biomedical Engineering,School of Pharmaceutical Sciences,Health Science Center,Shenzhen University,Shenzhen 518060,PR China [2]Guangdong Key Laboratory for Functional Substances in Medicinal Edible Resources and Healthcare Products,School of Life Sciences and Food Engineering,Hanshan Normal University,Chaozhou 521041,PR China

出　　处：《Organic Chemistry Frontiers》2022年第1期75-80,共6页有机化学前沿（英文）

基　　金：supported by the National Key Research and Development Program of China(2017YFA0503900);Shenzhen Government’s Plan of Science and Technology(JCYJ20170412110504956);the Shenzhen Fundamental Research Program(JCYJ20200109114225087);the National Science Fund for Distinguished Young Scholars(81525026);the Guangdong Key Laboratory for Functional Substances in Medicinal Edible Resources and Healthcare Products(2021B1212040015).

摘　　要：(±)-Cyclopeltains A and B(1 and 2),two pairs of unusual alkylated adenine derivatives,were isolated from the insect Cyclopelta parva and structurally characterized.1 and 2 both possess a 6/5/7/5 ring system arising from the alkylation of N^(7) and N^(10) by a C6 unit and the formation of a furan ring.A plausible biosynthetic pathway for 1 and 2 was proposed.Biological evaluation of the enantiomers of 1 and 2 revealed that(−)-1 and(+)-2 could inhibit the production of TNF-αand IL-6 and the expression of iNOS,COX-2,and p-NF-κB.

关 键 词：RING BASES structurally 

分 类 号：O62[理学—有机化学]