PEDV感染对宿主肠黏膜屏障和细胞影响的分子机制研究进展  

Research progress in the molecular mechanism of PEDV infection on host intestinal mucosal barrier and cells

作　　者：滑峰 呼延含蓉 张双[1] 赵艳丽[1] 郭衍冰 赵涵[1] 王开 伊淑帅[1,4] 牛江婷[1,4] 胡桂学 HUA Feng;HUYAN Hanrong;ZHANG Shuang;ZHAO Yanli;GUO Yanbing;ZHAO Han;WANG Kai;YI Shushuai;NIU Jiangting;HU Guixue(College of Veterinary Medicine,Jilin Agricultural University,Changchun 130118,China;Jilin Provincial Center for Animal Disease Control and Prevention,Changchun 130062,China;Jilin Academy of Animal Science and Veterinary Science,Changchun 130062,China;College of Animal Science and Technology,Jilin University of Agricultural Science and Technology,Jilin 132109,China)

机构地区：[1]吉林农业大学动物医学院,长春130118 [2]吉林省动物疫病预防控制中心,长春130062 [3]吉林省畜牧兽医科学研究院,长春130062 [4]吉林农业科技学院动物科技学院,吉林吉林132109

出　　处：《黑龙江畜牧兽医》2023年第12期19-22,共4页Heilongjiang Animal Science And veterinary Medicine

基　　金：国家自然科学基金项目(32072857)。

摘　　要：近年来,猪流行性腹泻(porcine epidemic diarrhea,PED)给我国畜牧业造成了严重的经济损失。随着人们对猪流行性腹泻病毒(Porcine epidemic diarrhea virus,PEDV)研究的深入,其致病机制也逐渐被揭晓,即PEDV进入宿主体内通过抑制干扰素的表达和诱导小肠细胞凋亡等机制对宿主产生严重影响。文章综述了PEDV蛋白组成及其对肠黏膜屏障和细胞影响的分子机制,以期为PED科学防控提供参考。In recent years,porcine epidemic diarrhea(PED)has caused serious economic loss to animal husbandry in China.With the deepening of researches on PEDV,its pathogenic mechanism has been gradually revealed,that is,PEDV inhibits the expression of interferon and induces apoptosis of some cells in small intestine after entering the host,which has a serious impact on the host.In this paper,the protein composition and structure of PEDV and the molecular mechanism of its effect on intestinal mucosal barrier and cells were reviewed,in order to provide reference for scientific PED prevention and control.

关 键 词：猪流行性腹泻病毒 结构蛋白 非结构蛋白 肠黏膜细胞 损伤 分子机制 

分 类 号：S851.3[农业科学—预防兽医学] S855.3[农业科学—兽医学]