基于in silico技术探究益母草在化妆品中的应用前景  

Research on the application prospect of motherwort in cosmetics based on in silico approach

作　　者：刘丽[1,2,3] 尹雅婷 程康 李惠 吕智 易帆 Li Liu;Yating Yin;Kang Cheng;Hui Li;Zhi Lv;Fan Yi(Key Laboratory of Cosmetic,China National Light Industry,Beijing Technology and Business University,Beijing 100048,China;Institute of Cosmetic Regulatory Science,Beijing Technology and Business University,Beijing 100048,China;Beijing Key Laboratory of Plant Research and Development,Beijing Technology and Business University,Beijing 100048,China;Shanghai Inoherb Cosmetics Co.,Ltd.,Shanghai 200444,China)

机构地区：[1]北京工商大学中国轻工业化妆品重点实验室,北京100048 [2]北京工商大学化妆品监管科学研究院,北京100048 [3]北京工商大学北京市植物资源研究开发重点实验室,北京100048 [4]上海相宜本草化妆品股份有限公司,上海200444

出　　处：《日用化学工业（中英文）》2023年第6期686-697,共12页China Surfactant Detergent & Cosmetics

基　　金：北京市教委一般科技项目(KM202010011009);北京市优秀人才培养资助青年骨干个人项目(2018000020124G032)。

摘　　要：益母草具有行血养血,活血化瘀的作用,临床应用广泛,常用来主治妇科疾病,近年来益母草的美容应用逐渐受到关注。本研究利用in silico技术平台,通过文献计量学对益母草的研究现状和未来的发展态势进行了预测,同时结合网络药理学对益母草皮肤美容的功效及物质基础进行预测,结果表明益母草的活性成分萜类化合物及益母草碱可通过NADPH、PDPK1、MAOB、VEGF2、SIRT2等靶点有效促进血液流动,改善皮肤微循环,调节激素代谢,降低炎症反应,抵御氧化应激,具有延缓皮肤老化,滋养皮肤的功效。本研究为益母草作为化妆品植物功效原料的物质基础及功效机理提供了理论基础,同时证明了益母草作为化妆品功效原料的独特性,具备良好的发展前景。Motherwort(Leonurus japonicas Houtt.) is a good gynecological medicine,which has the function of promoting circulation of blood,nourishing blood and activating circulation to remove blood stasis.It is widely used in clinical practice and commonly used to treat gynecological diseases,while the beauty application of motherwort has gradually attracted attention in recent year.This article built an in silico technology platform to present a systematic review of the literature concerning motherwort over the past two decades through bibliometrics to explore current research hotspots and predict the future development trends,and combine with network pharmacology to predict the efficacy and material basis of motherwort for skin beauty.The results show that terpenoids and alkali,the main active ingredient of motherwort,can effectively open blood vessles and expand blood passages to improve the facial skin blood micro-circulation and strengthen the skin's metabolism through NADPH,PDPK1,MAOB,VEGF2,SIRT2.In addition,they can regulate hormone metabolism to maintain the skin barrier,regulate the secretion of inflammatory factors to ease skin inflammation and involve in the regulation of cell-cycle to prevents oxidative stress-mediated skin aging by ER-α,ER-β,AKRAC3,CA2,HSP90AA1,MAPK14,CDK2 and other targets.Our research suggests that motherwort has the effect of delaying skin aging and nourishing skin.This study provides the theoretical basis for the material basis and efficacy mechanism of motherwort as a cosmetic plant efficacy raw material,and proves the uniqueness of motherwort as a cosmetic efficacy raw material,and has good development prospects.

关 键 词：益母草 化妆品 皮肤美容 in silico技术 文献计量 网络药理学 

分 类 号：TQ658[化学工程—精细化工]