抗MDA5-DM合并快速进展性间质性肺病的预后预测因素研究进展  

Research progress on prognostic predictive factors of anti-MDA5-DM combined with rapidly progressive interstitial lung disease

作　　者：王楠[1] 刘红菊[1] WANG Nan;LIU Hongju(Department of Respiratory and Critical Care Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei Province,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院呼吸与危重症医学科,湖北武汉430022

出　　处：《中国医药导报》2023年第16期50-53,79,共5页China Medical Herald

基　　金：湖北省自然科学基金面上项目(2018CKB907)。

摘　　要：抗黑色素瘤分化相关基因5抗体阳性皮肌炎是皮肌炎的一种特殊亚型,该类患者极易合并快速进展性间质性肺病,近年来经过呼吸科、风湿科及重症医学科医师的共同努力该病诊治已有很大进展,但在我国仍有较高的发病率和死亡率。全面评估影响患者预后的预测因素,对及时调整治疗方案并预判结局具有重要意义。本文整理了近几年的国内外相关研究,将从多方面对抗黑色素瘤分化相关基因5抗体阳性皮肌炎合并快速进展性间质性肺病患者的预后预测因素的研究进展进行综述。Anti-melanoma differentiation associated gene 5 antibody-positive dermatomyositis is a special subtype of dermatomyositis,which is very easy to be associated with rapidly progressive interstitial lung disease.In recent years,great progress has been made in the diagnosis and treatment of the disease through the joint efforts of doctors from respiratory department,rheumatology department,and severe medical department,but there are still high incidence rates and mortality rates in China.Comprehensive evaluation of predictive factors affecting patient prognosis is of great significance for timely adjustment of treatment plans and predicting outcomes.This article mainly summarizes the relevant domestic and foreign researches in recent years,and reviews research progress on the progress of predictive factors in anti-melanoma differentiation associated gene 5 antibody-positive dermatomyositis is combined with rapidly progressive interstitial lung disease.

关 键 词：间质性肺病 抗黑色素瘤分化相关基因5抗体 皮肌炎 预测因素 

分 类 号：R563.1[医药卫生—呼吸系统]