干细胞治疗宫腔内膜粘连相关分子信号通路的研究进展  

Advances in molecular signaling pathways related to endometrial adhesions treated by stem cells related molecular signaling pathways

作　　者：马国慧 黄艳红 MA Guohui;HUANG Yanhong(Department of Clinical Medicine of Chinese and Western Medicine,the First Clinical Medical College of Shaanxi University of Chinese Medicine,Shaanxi Province,Xianyang 712046,China;Department of Reproductive Endocrinology,Xi’an International Medical Center Hospital,Shaanxi Province,Xi’an 710100,China)

机构地区：[1]陕西中医药大学第一临床医学院中西医临床医学系,陕西咸阳712046 [2]西安国际医学中心医院生殖内分泌科,陕西西安710100

出　　处：《中国医药导报》2023年第16期58-61,共4页China Medical Herald

基　　金：陕西省重点产业创新链(群)-社会发展领域研发计划项目(2020ZDLSF03-01)。

摘　　要：子宫腔粘连(IUA)是由于感染,流产及反复宫腔操作导致的子宫内膜损伤并发生异常粘连,是导致不孕症的一个重要原因。目前,针对IUA的治疗,轻中度患者通过传统治疗方法尚能取得一定疗效,但对于重度或广泛内膜损伤的患者,子宫内膜再生和功能恢复已成为临床上棘手的问题。随着干细胞的广泛研究,具备免疫原性低、增殖分化等优势的干细胞被认为是治疗IUA中最潜在的方法之一。既往研究表明,干细胞的旁分泌作用能够通过分泌生长因子、抑制病灶区域炎症反应,从而促进新生血管的形成及改善子宫内膜纤维化。本文综述了干细胞治疗IUA的现有的分子机制,以期对未来的研究起到指导作用。Intrauterine adhesion(IUA)is an important cause of infertility due to endometrial injury and abnormal adhesion caused by infection,abortion and repeated intrauterine operations.At present,for the treatment of IUA,mild to moderate patients can still achieve a certain effect through traditional treatment,but for patients with severe or extensive endometrial injury,endometrial regeneration and functional recovery has become a clinical thorny problem.With the extensive research of stem cells,stem cells with low immunogenicity,proliferation and differentiation advantages are considered to be one of the most potential methods in the treatment of intrauterine adhesions.Previous studies have shown that the paracrine effect of stem cells can promote the formation of new blood vessels and improve intrauterine fibrosis by secreting growth factors and inhibiting inflammation in the lesion area.In this paper,we review the existing molecular mechanisms of stem cell therapy for intrauterine adhesions in order to provide guidance for future research.

关 键 词：子宫腔粘连 干细胞 不孕症 分子机制 

分 类 号：R71[医药卫生—妇产科学]