Efficacy and safety of mild-warm moxibustion in treating diarrhea-predominant irritable bowel syndrome(spleen deficiency and dampness excess syndrome):a study protocol for a randomized controlled trial  

作　　者：Yun-Yi Chen Jing Gu Yu-Hui Wang Hua Huang Li-Ying Fang Qian Fan Li-Jiang Ji 

机构地区：[1]Department of Anorectal Surgery,Changshu Hospital Affiliated to Nanjing University of Chinese Medicine,Changshu 215500,China [2]School of Integrative Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China [3]Department of gastroenterology,Changshu Hospital Affiliated to Nanjing University of Chinese Medicine,Changshu 215500,China [4]Department of Acupuncture,Changshu Hospital Affiliated to Nanjing University of Chinese Medicine,Changshu 215500,China

出　　处：《TMR Non-Drug Therapy》2023年第2期1-11,共11页TMR非药物治疗

基　　金：This work is supported by Jiangsu Traditional Chinese Medicine Science and Technology Development Project(No.MS2021058);Natural Science Foundation of Nanjing University of Chinese Medicine(No.XZR2020062);Suzhou Municipal Science and Technology Bureau Supporting Project(No.SKY2022072);Open Project of Zhenjiang Traditional Chinese Medicine Spleen and Stomach Diseases Clinical Medicine Research Center(No.SSPW2022-KF08);Changshu Municipal Science and Technology Bureau Supporting Project(No.CS202030).

摘　　要：1Background:Irritable bowel syndrome(IBS)is a disorder of bowel function,and diarrhea-predominant irritable bowel syndrome(IBS-D)is the most common.The current treatment for IBS-D is focused on improving patients’gastrointestinal-related symptoms,but there are limitations such as unstable effects and adverse drug reactions.Acupuncture and moxibustion exerts advantages in treating IBS-D.They include several forms,of which moxibustion is one of the most commonly used.And moxibustion is a common way used in treating IBS-D,but there is a lack of relevant evidence-based medical research data.This protocol aims to compare the efficacy of moxibustion(mild-warm moxibustion)in treating IBS-D(spleen deficiency and dampness excess syndrome)with the first-line treatment.Methods:In this prospective,parallel,randomized controlled trial(RCT)protocol,patients will be randomly allocated for 4-week treatment or control therapies and then 4-week follow-up in both groups.We will use Irritable Bowel Syndrome-Symptom Severity Scale(IBS-SSS)score,Irritable Bowel Syndrome-Quality of Life(IBS-QOL)score,serum brain-gut peptide levels,and traditional Chinese medicine(TCM)syndrome scale score to produce more evidence on IBS-D treatment with moxibustion.Finally,we will use SPSS 22.0 software to statistically analyze the data.Discussion:Mild-warm moxibustion is a complementary alternative therapy that fits with the pathogenesis of IBS-D.We hope to see more clinical evidence for mild-warm moxibustion against IBS-D that this RCT supported.

关 键 词：IBS-D mild-warm moxibustion protocol complementary alternative therapy randomized controlled trial 

分 类 号：R24[医药卫生—中医临床基础]