Fromα-keto acids to nitrile oxides enabled by copper nitrate:a facile access to fused isoxazolines  

作　　者：Yuping Zhu Tianqi Liu Bingxin Liu Houguang Shi Qitao Tan Bin Xu 

机构地区：[1]Department of Chemistry,Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong),Shanghai Engineering Research Center of Organ Repair,Innovative Drug Research Center,School of Medicine,Shanghai University,Shanghai 200444,China [2]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Organic Chemistry Frontiers》2022年第3期676-681,共6页有机化学前沿（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(21871174,22171178,21971159);Innovation Program of Shanghai Municipal Education Commission(2019-01-07-00-09-E00008).The authors thank Prof.Chang-Hua Ding and Dr Mingchun Gao for their helpful discussions.Also,many thanks to Ms Jianjian Zha and Mr Shaohang Lu for performing the experiments for the revision.

摘　　要：α-Keto acids were unprecedentedly employed as novel precursors of nitrile oxides on treatment with copper nitrate,which reacted with maleimides via[3+2]dipolar cycloaddition leading to pharmacologically interesting fused isoxazolines.This approach offers a unique strategy and complementary method for the convenient generation of alkyl substituted nitrile oxides.

关 键 词：NITRATE FUSED OXIDES 

分 类 号：O62[理学—有机化学]