新生儿期结核病的诊治与管理  

Treatment and management of tuberculosis in newborns

作　　者：焦伟伟 蒋婷婷[2] 申阿东 Jiao Wei-Wei;Jiang Ting-Ting;Shen A-Dong(Beijing Key Laboratory of Pediatric Respiratory Infection Disease/National Clinical Research Center for Respiratory Diseases/Key Laboratory of Major Diseases in Children,Ministry of Education/National Key Discipline of Pediatrics(Capital Medical University)/Beijing Pediatric Research Institute/Beijing Children’s Hospital,Capital Medical University/National Center for Children’s Health,Beijing 100045,China;Baoding Key Laboratory for Precision Diagnosis and Treatment of Infectious Diseases in Children/Baoding Hospital of Beijing Children’s Hospital,Capital Medical University,Baoding,Hebei 071051,China)

机构地区：[1]国家儿童医学中心/首都医科大学附属北京儿童医院/北京市儿科研究所/儿科学国家重点学科/儿科重大疾病研究教育部重点实验室/国家呼吸系统疾病临床医学研究中心/儿童呼吸道感染性疾病研究北京市重点实验室,北京100045 [2]首都医科大学附属北京儿童医院保定医院/保定市儿童感染性疾病精准诊治重点实验室,河北保定071000

出　　处：《解放军医学杂志》2023年第6期648-652,共5页Medical Journal of Chinese People's Liberation Army

基　　金：北京市卫生健康委员会高层次公共卫生技术人才培养计划(2022-3-041)。

摘　　要：结核病仍然是严重危害公众健康的重要疾病。新生儿期结核病包括先天性结核病和新生儿结核病,尽管并不常见,但由于进展迅速、病死率高,临床医师应予以重视。先天性结核病从母亲垂直传播而来,新生儿结核病则是在出生后通过接触传染性结核病患者而获得,两者在临床上通常难以区分,但治疗和管理是相同的。本文从新生儿期结核病的产前管理(即妊娠结核病的流行现状、早期识别和合理治疗)及产后管理(即高危患儿的评估和治疗)两个方面进行论述,以期为临床医师早期识别新生儿期结核病、采取合理有效的治疗措施提供参考。Tuberculosis(TB)is still a big threat to public health.TB in newborns includes congenital TB and neonatal TB.Although not common,rapid progress and high mortality rates must attract the attention of clinicians.Congenital TB is transmitted vertically from mother,mainly acquired in utero through haematogenous spread via the umbilical cord or at the time of delivery through aspiration or ingestion of infected amniotic fluid or cervicovaginal secretions.Neonatal TB is acquired after birth through exposure to a person with infectious TB.It is often difficult to distinguish congenital TB and neonatal TB.But treatment and management is the same.This paper discusses the prenatal(epidemiology,early detection and reasonable treatment of TB in pregnancy)and postpartum(evaluation and treatment of newborns with high risk factors for TB)management of tuberculosis in newborns in order to provide useful information for clinicians to identify congenital tuberculosis and neonatal tuberculosis in the early stage and take reasonable and effective treatment measures as soon as possible.

关 键 词：结核病 新生儿感染 管理 

分 类 号：R722.13[医药卫生—儿科]