gem-Difluorovinylation of alkynyl bromoarenes via dual nickel-/palladium-catalyzed crosselectrophile coupling  

作　　者：Haotian Sun Baojian Xiong Yuan Yang Jiangjun Liu Xuemei Zhang Zhong Lian 

机构地区：[1]Department of Dermatology,State Key Laboratory of Biotherapy and Cancer Center,National Clinical Research Center for Geriatrics,West China Hospital and West China School of Pharmacy,Sichuan University,Chengdu 610041,China

出　　处：《Organic Chemistry Frontiers》2022年第2期305-310,共6页有机化学前沿（英文）

基　　金：supported by National Natural Science Foundation of China(21901168);“1000-Youth Talents Plan”;Sichuan Science and Technology Program(2021YJ0395);“1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University”.

摘　　要：A dual nickel-/palladium-catalyzed gem-difluorovinylation of alkynyl bromoarenes is presented.This method proceeds smoothly to afford various dihydrobenzofuran compounds containing gem-difluorovinyl fragments with excellent stere-oselectivities in moderate to excellent yields.This strategy also features good functional group tolerance.Mechanistic studies reveal that the C-OTs bond and C-Br bond are selectively oxidative-added by nickel and palladium complexes respec-tively,and palladium is the center metal in the reductive elimination step.

关 键 词：PALLADIUM NICKEL VINYL 

分 类 号：O62[理学—有机化学]