Enantioselective construction of a congested quaternary stereogenic center in isoindolinones bearing three aryl groups via an organocatalytic formal Betti reaction  

作　　者：Arben Berisa Danijel Glavac Chao Zheng Shu-Li You Matija Gredicak 

机构地区：[1]Division of Organic Chemistry and Biochemistry,Ruder Boskovic Institute,Bijenicka c.54,10000 Zagreb,Croatia [2]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,345 Lingling Lu,Shanghai 200032,China

出　　处：《Organic Chemistry Frontiers》2022年第2期428-435,共8页有机化学前沿（英文）

基　　金：provided by the Croatian Science Foundation(grant no.IP-2018-01-4053);Science and Technology Commission of Shanghai Municipality(grant no.19590750400).

摘　　要：An efficient enantioselective formal Betti reaction between phenols and diaryl ketimines generated in situ from isoindolinone alcohols is described.In a reaction catalyzed by a chiral phosphoric acid,a broad range of ketimines and phenols afforded isoindolinone derivatives comprising a congested quaternary stereogenic center bearing three aryl groups in high yields,and high regioselectivities and enantioselectivities.

关 键 词：QUATERNARY FORMAL STEREO 

分 类 号：O62[理学—有机化学]