Synthesis of the C50 diastereomers of the C33–C51 fragment of stambomycin D  

作　　者：Yongchen Wang Venkaiah Chintalapudi Haraldur G.Gudmundsson Gregory L.Challis Edward A.Anderson 

机构地区：[1]Chemistry Research Laboratory,University of Oxford,12 Mansfield Road,Oxford,OX13TA,UK [2]Department of Chemistry and Warwick Integrative Synthetic Biology Centre,University of Warwick,Coventry,CV47AL,UK [3]Department of Biochemistry and Molecular Biology and ARC Centre of Excellence for Innovations in Peptide and Protein Science,Biomedicine Discovery Institute,Monash University,Clayton,Victoria 3800,Australia

出　　处：《Organic Chemistry Frontiers》2022年第2期445-449,共5页有机化学前沿（英文）

基　　金：the Marie Skłodowska-Curie actions for an Individual Fellowship(V.C.,GA No.702385);the Leverhulme Trust for funding(H.G.G.,RPG-2015-003);the EPSRC for additional support(EP/S013172/1).

摘　　要：As products of genome mining,the stereochemical assignment of the macrolide antibiotics stambomycins A-D has been made on the basis of sequence analysis of the associated polyketide synthase,aside from two stereocentres at C28 and C50.Here we describe syntheses of the two C50 diastereomers of the C33-C51 region of the stambomycins,which support the PKS-based configurational assignment,and establish a strategy suitable for access to the extended stambomycin framework.

关 键 词：stereo ASSIGNMENT CENTRE 

分 类 号：O62[理学—有机化学]