Regio-and enantioselective formation of tetrazole-bearing quaternary stereocenters via palladium-catalyzed allylic amination  

作　　者：Shahid Khan Yu Wang Mei-Na Zhang Shahida Perveen Junjie Zhang Ajmal Khan 

机构地区：[1]Department of Chemistry,School of Chemistry,Xi’an Key Laboratory of Sustainable Energy Materials Chemistry and MOE Key Laboratory for Non-equilibrium Synthesis and Modulation of Condensed Matter,Xi’an Jiao Tong University,Xi’an 710049,P.R.China

出　　处：《Organic Chemistry Frontiers》2022年第2期456-461,共6页有机化学前沿（英文）

基　　金：supported by the“Fundamental Research Funds for Central Universities”(No.1191329135);the Key Laboratory Construction Program of Xi’an Municipal Bureau of Science and Technology(No.201805056ZD7CG40);the starting fund of Xi’an Jiao Tong University(No.7121182002).

摘　　要：Based on palladium-catalyzed allylic amination reaction,the first general example of enantioselective formation of a tetrazole-bearing quaternary stereocenter has been developed.The protocol uses ambivalent tetrazole and vinyl cyclic carbonates as easily available coupling partners.This operationally simple methodology is further characterized by its wide substrate scope,high enantioselectivity and excellent branched to linear regioselectivity,thus unlocking a new platform that permits the synthesis of elusive quaternary N2-allylic tetrazoles,even in the context of late-stage functionalization.

关 键 词：QUATERNARY PALLADIUM catalyzed 

分 类 号：O62[理学—有机化学]