Copper-catalyzed oxidative phosphonoheteroarylation of alkenes with phosphonates and N-heteroarenes via P-H/C-H functionalization  

作　　者：Chong-Hui Xu Zhi-Qiang Xiong Yang Li Yan-Ping Zhu Jin-Heng Li 

机构地区：[1]Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle,Nanchang Hangkong University,Nanchang 330063,China [2]School of Pharmacy,Key Laboratory of Molecular Pharmacology and Drug Evaluation,Ministry of Education,Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong,Yantai University,Yantai,Shandong,264005,China [3]State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000,China [4]School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang,Henan 475004,China

出　　处：《Organic Chemistry Frontiers》2022年第2期476-480,共5页有机化学前沿（英文）

基　　金：the National Natural Science Foundation of China(No.21625203 and 21871126);the Jiangxi Province Science and Technology Project(No.20182BCB22007,20202ACB203002,and 20202BAB213004);the Talent Induction Program for Youth Innovation Teams in Colleges and Universities of Shandong Province;the Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University(No.2021ZD01)for financial support.

摘　　要：A copper-catalyzed oxidative intermolecular phosphonoheteroarylation of alkenes with phosphonates and nucleophilic N-heteroarenes(such as indoles and pyrroles)involving P-H/C-H functionalization for the synthesis of highly valuable β-(N-heteroaryl)-alkylphosphonates is disclosed.This method allows the incorporation of two functional groups,a phosphonate and a N-heteroarene,into the alkene in a single reaction step through oxidative formation of the P-centered radicals,addition across the CvC bond,single electron oxidation and C-H functionalization cascades.

关 键 词：OXIDATIVE PHOSPHONATE catalyzed 

分 类 号：O62[理学—有机化学]