The applications of catalytic asymmetric halocyclization in natural product synthesis  

作　　者：Jiahang Yan Zhiqiang Zhou Qiaoqiao He Guzhou Chen Hongbo Wei Weiqing Xie 

机构地区：[1]Shaanxi Key Laboratory of Natural Products&Chemical Biology,College of Chemistry&Pharmacy,Northwest A&F University,22 Xinong Road,Yangling 712100,Shaanxi,China [2]Key Laboratory of Botanical Pesticide R&D in Shaanxi Province,Yangling,Shaanxi 712100,China

出　　处：《Organic Chemistry Frontiers》2022年第2期499-516,共18页有机化学前沿（英文）

基　　金：grateful for financial support from the National Natural Science Foundation of China(grants 21722206,21672171);Financial support from the Scientific Fund of Northwest A&F University is also acknowledged.

摘　　要：Halocyclization of olefinic substrate enables the establishment of cyclic skeletons via intramolecular halonium-induced nucleophilic addition,which has been well utilized as a practical strategy for constructing cyclic skeletons in natural product synthesis.Recently,the renaissance and rapid evolution of organocatalysis have accelerated the development of catalytic asymmetric halocyclization.In this context,natural product synthesis powered by catalytic asymmetric halocyclization has also achieved considerable progress in recent years.In some cases,these newly developed protocols enable more concise synthetic routes for accessing enantioenriched natural products.To this end,this review summarizes the applications of catalytic asymmetric halocyclization in natural product synthesis.

关 键 词：synthesis. CYCLIZATION ASYMMETRIC 

分 类 号：O62[理学—有机化学]