Central Granular Cell Odontogenic Tumor: A Literature Review of Cases Reported in the Last 71 Years with a New Case Report  

作　　者：Fatemeh Mashhadiabbas Sanaz GholamiToghchi Roohollah Safarpour 

机构地区：[1]Department of Oral and Maxillofacial Pathology,School of Dentistry,Shahid Beheshti University of Medical Sciences,Tehran 1983969413,Iran [2]Department of Oral and Maxillofacial Pathology,School of Dentistry,Lorestan University of Medical Sciences,Khorramabad 6813833946,Iran

出　　处：《Chinese Medical Sciences Journal》2023年第2期138-146,共9页中国医学科学杂志（英文版）

摘　　要：Central granular cell odontogenic tumors(CGCOTs)are rare,benign,slowly growing odontogenic neoplasms.Due to their uncertain histogenesis,CGCOTs are still not included as a distinct entity in the WHO classification(2017)of odontogenic tumors.We report a case of CGCOT involving the right side of maxillary anterior region of a 39-year-old white female.Immunohistochemical staining showed that granular cells positively expressed CD68 and vimentin,and negatively expressed S-100 protein.Meanwhile,we searched Pub Med,Google Scholar,and Scopus databases to summary the clinico-pathological features of 51 reported cases of CGCOT.The results showed that the granular cells of 28.6%cases were immunopositive for vimentin and CD68,and odontogenic epithelial cells were positive immunoreactivity for cytokeratin.These findings reinforced the mesenchymal origin of granular cells and the odontogenic nature of epithelium islands.

关 键 词：central granular cell odontogenic tumor central granular cell odontogenic fibroma odontogenic tumor granular cell ameloblastic fibroma HISTOGENESIS 

分 类 号：R714.25[医药卫生—妇产科学]