蜈蚣败毒饮对银屑病不同血分证型患者皮损指数、中医证候评分及血液学检验指标的影响  

Effect of Wugong Baidu Decoction on Skin Damage Index,TCM Syndrome Score,and Hematological Test Indexes in Psoriasis with Different Blood Aspect Syndromes

作　　者：袁锐[1] 孙起超 安月鹏[1] 张晴[1] 闫景东[1] 周妍妍[2] YUAN Rui;SUN Qichao;AN Yuepeng;ZHANG Qing;YAN Jingdong;ZHOU Yanyan(The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China;Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040 [2]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中医药学报》2023年第7期84-90,共7页Acta Chinese Medicine and Pharmacology

基　　金：国家自然科学基金项目(81973846);黑龙江省中医药科研项目(LHY2022-132)。

摘　　要：目的:探讨蜈蚣败毒饮对银屑病血热证、血瘀证、血燥证型患者皮损指数、血液学检验指标的影响,并探讨其相关机制。方法:将符合纳入标准的300例寻常型银屑病患者采用随机数字表法分为治疗组和对照组,每组再分为血热证、血燥证、血瘀证组,除脱落病例外,最终治疗组141例,对照组146例。治疗组给予蜈蚣败毒饮水煎剂,每日1剂,每日2次;对照组给予复方甘草酸苷片,每次2片,每日3次,各组患者均连续给药4周。观察两组不同证型患者临床疗效,比较治疗前后两组银屑病皮损面积和严重程度指数(PASI)、中医证候评分、8项血液学检测指标[C反应蛋白(CRP)、前白蛋白(PA)、降钙素原(PCT)、白细胞计数(WBC)、红细胞沉降率(ESR)、载脂蛋白A(APOA)、载脂蛋白B(APOB)、纤维蛋白原(FIB)]水平。结果:治疗组各证型患者临床疗效均高于对照组同证型患者(P<0.01)。治疗前各组患者的PASI评分、各项血液学指标差异无统计学意义(P>0.05);与本组治疗前比较,治疗后的治疗组的PASI评分、中医证候评分均显著降低(P<0.01),CRP、PCT、WBC、ESR、APOB、FIB水平显著下降(P<0.01)、PA、APOA水平显著升高(P<0.01);且治疗组PASI评分、中医证候评分以及CRP、PCT、WBC、ESR、APOB、FIB水平低于同证型对照组(P<0.05),PA、APOA水平高于同证型的对照组(P<0.05);且治疗组内的血瘀证组、血热证型PASI评分、中医证候评分以及CRP、PCT、WBC、ESR、APOB、FIB水平低于血燥证组(P<0.01),PA、APOA水平高于同证型的对照组(P<0.05)。结论:蜈蚣败毒饮可显著改善银屑病血热证、血瘀症型患者皮损状态、中医症候表现以及血液学检测指标水平,其机制可能与调节炎症、血脂、血液黏度因子有关。Objective:To explore the effects of Wugong Baidu Decoction(WBD)on skin lesion index and hematological test indexes in psoriasis with blood heat syndrome,blood stasis syndrome,and blood dryness syndrome,and to explore its related mechanisms.Methods:300 patients with psoriasis vulgaris who met the inclusion criteria were randomly divided into a treatment group and a control group using a random number table.Each group was further divided into blood heat syndrome,blood dryness syndrome,and blood stasis syndrome subgroups.Except for dropouts,there were 141 patients for analysis in treatment group,and 146 patients in control group.The treatment group was given WBD,one dose a day,twice daily;the control group was given compound glycyrrhizin tablets,two tablets a time,three times a day;and all patients were treated continuously for four weeks.The clinical efficacy of the two group was observed,and the psoriasis lesion area and severity index(PASI),TCM syndrome scores,and eight hematological test indexes[C-reactive protein(CRP),prealbumin(PA),procalcitonin(PCT),white blood cell(WBC)count,erythrocyte sedimentation rate(ESR),apolipoprotein A(APOA),apolipoprotein B(APOB),and fibrinogen(FIB)]levels before and after the treatment were compared.Results:The clinical efficacy of patients with various syndrome types in the treatment group was higher than that of patients with the same syndrome type in the control group(P<0.01).Before the treatment,there was no significant difference in PASI score and various hematological indexes among the groups(P>0.05).The PASI score and TCM syndrome score of each treatment group after the treatment were significantly decreased(P<0.01),the levels of CRP,PCT,WBC,ESR,APOB,and FIB were significantly decreased(P<0.01),and the levels of PA and APOA were significantly increased(P<0.01).In addition,for the treatment group,PASI score,TCM syndrome score,and the levels of CRP,PCT,WBC,ESR,APOB,and FIB were lower than those of the same syndrome type control group(P<0.05),while the levels of PA and APOA wer

关 键 词：蜈蚣败毒饮 银屑病 皮损指数 血液学检验 

分 类 号：R275.863[医药卫生—中医皮科]