硝苯地平结合厄贝沙坦氢氯噻嗪对中重度高血压患者的疗效分析  

Efficacy analysis of nifedipine combined with irbesartan and hydrochlorothiazide in the treatment of moderate to severe hypertension

作　　者：赵芳 ZHAO Fang(Balizhuang Second Community Health Service Center of Chaoyang District,Beijing 100123,China)

机构地区：[1]北京市朝阳区八里庄第二社区卫生服务中心,100123

出　　处：《中国实用医药》2023年第12期114-117,共4页China Practical Medicine

摘　　要：目的 探讨中重度高血压患者接受硝苯地平结合厄贝沙坦氢氯噻嗪治疗的效果。方法 80例中重度高血压患者,根据治疗方法不同分为对照组和观察组,每组40例。对照组患者仅采用硝苯地平治疗,观察组患者在对照组基础上结合厄贝沙坦氢氯噻嗪治疗。比较两组治疗前后血压水平,治疗效果,治疗前后生活质量评分。结果 治疗前,两组患者的收缩压和舒张压水平比较差异无统计学意义(P>0.05);治疗后,两组患者的收缩压和舒张压水平均较治疗前有所降低,观察组患者的收缩压(125.09±7.34)mm Hg(1 mm Hg=0.133 kPa)和舒张压(80.59±7.12)mm Hg均明显低于对照组的(140.65±7.63)、(90.17±6.34)mm Hg,差异具有统计学意义(P<0.05)。观察组患者的治疗总有效率为95.00%,显著高于对照组的77.50%,差异具有统计学意义(P<0.05)。治疗前,两组患者的生理状况、社会功能、自理行为、情感状况、精神状况、生命活力以及总健康评分比较差异无统计学意义(P>0.05);治疗后,两组患者的生理状况、社会功能、自理行为、情感状况、精神状况、生命活力以及总健康评分均较治疗前有所提升,且观察组患者的生理状况评分(83.48±6.32)分、社会功能评分(84.43±5.22)分、自理行为评分(84.56±7.76)分、情感状况评分(84.93±7.12)分、精神状况评分(80.66±5.37)分、生命活力评分(83.04±5.33)分以及总健康评分(83.52±6.71)分均明显高于对照组的(80.24±5.21)、(81.15±6.17)、(79.42±8.33)、(79.73±7.62)、(74.14±5.52)、(79.85±5.19)、(79.09±6.17)分,差异具有统计学意义(P<0.05)。结论 中重度高血压患者接受硝苯地平结合厄贝沙坦氢氯噻嗪治疗,对促进自身血压稳定、改善患者生活质量有显著作用。Objective To discuss the effect of nifedipine combined with irbesartan and hydrochlorothiazide in the treatment of moderate to severe hypertension.Methods A total of 80 patients with moderate to severe hypertension were divided into control group and observation group according to different treatment methods,with 40 cases in each group.The control group was treated with nifedipine alone,and the observation group was treated with irbesartan and hydrochlorothiazide on the basis of the control group.The blood pressure level,therapeutic effect and quality of life score before and after treatment were compared between the two groups.Results Before treatment,there was no statistically significant difference in systolic blood pressure and diastolic blood pressure between the two groups(P>0.05).After treatment,the systolic blood pressure and diastolic blood pressure were decreased in both groups compared with those before treatment in this group;systolic blood pressure of(125.09±7.34)mm Hg(1 mm Hg=0.133 kPa)and diastolic blood pressure of(80.59±7.12)mm Hg in the observation group were significantly lower than those of(140.65±7.63)and(90.17±6.34)mm Hg in the control group;the differences were statistically significant(P<0.05).The total effective rate of 95.00%in the observation group was significantly higher than that of 77.50%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in scores of physiological status,social function,self-care behavior,emotional status,mental status,vital vitality and total health between the two groups(P>0.05).After treatment,the scores of physiological status,social function,self-care behavior,emotional status,mental status,vital vitality and total health in the two groups were improved compared with those before treatment in this group;in the observation group,the physiological status score was(83.48±6.32)points,the social function score was(84.43±5.22)points,the self-care behavior score was(8

关 键 词：中重度高血压 硝苯地平 厄贝沙坦氢氯噻嗪 生活质量 

分 类 号：R544.1[医药卫生—心血管疾病]