CT/MR增强检查中对比剂对新生儿肾功能的影响  

Effects of Contrast Medium on Renal Function of Neonates in CT/MR Enhanced Examination

作　　者：赵晓玉[1] 卢晓静 史香芬[1] 高松伟 张旭锋 邢进远 张晓坚[1] Zhao Xiaoyu;Lu Xiaojing;Shi Xiangfen;Gao Songwei;Zhang Xufeng;Xing Jinyuan;Zhang Xiaojian(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院,郑州450052

出　　处：《儿科药学杂志》2023年第7期45-48,共4页Journal of Pediatric Pharmacy

摘　　要：目的:探讨电子计算机断层扫描(CT)和核磁共振(MR)增强检查中对比剂对新生儿肾功能的影响及年龄与肾功能指标的相关性。方法:回顾性分析2017年1月至2021年5月郑州大学第一附属医院接受CT/MR检查的81例新生儿临床资料,根据是否实施增强检查分为对比剂组38例和对照组43例,统计并比较两组患儿临床资料、检查时的年龄、体质量及检查不同时间点的年龄、血肌酐(Scr)和肾小球滤过率(GFR),分析新生儿年龄与肾功能指标的相关性。结果:两组患儿性别、是否早产、娩出方式、检查方式、镇静剂应用、原发病分布等比较差异无统计学意义(P>0.05)。两组患儿检查时的年龄、体质量以及检查不同时间点的年龄、Scr、GFR水平比较,差异均无统计学意义(P>0.05)。Spearman相关性分析显示,Scr水平与年龄呈负相关(r=-0.606,P<0.01),GFR水平与年龄呈正相关(r=0.508,P<0.01)。结论:新生儿在CT/MR增强检查中应用对比剂对其肾功能无明显影响,新生儿年龄与Scr水平呈负相关,与GFR水平呈正相关。Objective:To probe into the effects of contrast medium on renal function of neonates in computed tomography(CT)and magnetic resonance(MR)enhanced examination and the correlation between age and renal function indicators.Methods:Clinical data of 81 neonates received CT/MR examination in the First Affiliated Hospital of Zhengzhou University from Jan.2017 to May 2021 were retrospectively analyzed.All patients were divided into 38 cases in the contrast group and 43 cases in the control group according to whether enhancement test was performed.The general data,age at the time of examination,body mass,age,serum creatinine(Scr)and glomerular filtration rate(GFR)at different time points of two groups were collected and compared.The correlation between neonatal age and renal function was analyzed.Results:There was no significant difference in gender,premature delivery,delivery method,examination method,sedative application and primary disease distribution between two groups(P>0.05).There was no statistically significant difference between the age at the time of examination and body mass,age,Scr and GFR at different time points(P>0.05).Spearman correlation analysis showed that Scr was negatively correlated with age(r=-0.606,P<0.01),GFR was positively correlated with age(r=0.508,P<0.01).Conclusion:The application of contrast medium in CT/MR enhanced examination has no significant effect on renal function of neonates.Neonatal age was negatively correlated with Scr levels and positively correlated with GFR levels.

关 键 词：对比剂 新生儿 肾功能 电子计算机断层扫描 核磁共振 

分 类 号：R729[医药卫生—儿科]