幼童脑干形态学与增龄发育的数字化特征  

Digital characteristics of brainstem morphology and age-related development in young children

作　　者：刘亚楠 王星 李琨[2,3] 孙瑞芬 马雪英[5] 赵磊[5] 刘宇航 杨洋[1] 郝韵腾 李梓瑜[1] 张少杰 李志军 Liu Yanan;Wang Xing;Li Kun;Sun Ruifen;Ma Xueying;Zhao Lei;Liu Yuhang;Yang Yang;Hao Yunteng;Li Ziyu;Zhang Shaojie;Li Zhijun(Graduate School of Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia Autonomous Region,China;Department of Anatomy,School of Basic Medicine,Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia Autonomous Region,China;Center for Digital Medicine,Inner Mongolia Medical University,Hohhot 010059,Inner Mongolia Autonomous Region,China;Department of Imaging,Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010000,Inner Mongolia Autonomous Region,China;Department of Imaging,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010030,Inner Mongolia Autonomous Region,Chin)

机构地区：[1]内蒙古医科大学研究生院,内蒙古自治区呼和浩特市010110 [2]内蒙古医科大学基础医学院解剖学教研室,内蒙古自治区呼和浩特市010110 [3]内蒙古医科大学数字医学中心,内蒙古自治区呼和浩特市010059 [4]内蒙古医科大学第二附属医院影像中心,内蒙古自治区呼和浩特市010000 [5]内蒙古医科大学附属医院影像中心,内蒙古自治区呼和浩特市010030

出　　处：《中国组织工程研究》2024年第11期1730-1736,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81860383);内蒙古自然科学基金(2020LH08021),项目负责人:李志军;国家自然科学基金(81860382);内蒙古自然科学基金(2020MS03061);内蒙古高等学校青年科技英才支持计划(NJYT22009);内蒙古自治区科技计划(2019GG158);内蒙古医科大学科研重点项目(YKD2021ZD011);内蒙古卫生健康委医疗卫生科技计划(202201217),项目负责人:王星;内蒙古自然科学基金(2019MS08017),项目负责人:张少杰;内蒙古自然科学基金(2022QN03002);内蒙古医科大学青年基金(YKD2020QNCX055),项目负责人:李琨。

摘　　要：背景:既往对脑干研究多集中于成人和胎儿,而对国人幼童脑干的增龄发育特征研究甚少。目的:观测健康幼童脑干发育特征,探究其增龄差异及其与性别间的相关性。方法:2019年1月至2022年4月对内蒙古医科大学附属医院174例2-6岁幼童颅颈部3.0T MRI图像行回顾性研究,测量脑干(含中脑、脑桥、延髓)正中矢状面径线、面积和角度。结果与结论:中脑、脑桥、延髓前后径在2-5岁组,中脑、脑桥、延髓纵径和面积在2-6岁组总体随增龄呈递增趋势,除延髓纵径外均呈正相关(r>0,P<0.05),在2-3岁组、4-5岁组期间处于快速生长发育阶段,这2个年龄组可作为幼童发育重点观测指标;脑桥前后径、纵径、面积和脑干总面积与年龄相关性较强,可作为其脑干发育重点观测指标。BACKGROUND:Previous brain studies have mostly focused on adults and fetuses,and the developmental characteristics of young children's brainstems have rarely been studied.OBJECTIVE:To observe the brainstem development characteristics of healthy young children and to explore the age-related differences and their correlation with sex.METHODS:From January 2019 to April 2022,a retrospective study of 3.0T MRI images of 174 children aged 2 to 6 years in the Affiliated Hospital of Inner Mongolia Medical University was conducted,and the median sagittal diameter,area and angle of the brainstem(including midbrain,pons and medulla oblongata)were measured.RESULTS AND CONCLUSION:There is an age-related increase in the anterior and posterior diameters of the midbrain,pons and medulla oblongata in the 2-5 years old group as well as in the longitudinal diameter and area of the midbrain,pons and medulla oblongata in the 2-6 years old group.Except for the longitudinal diameter of the medulla oblongata,all others show a positive correlation with age(r>0,P<0.05).In the 2-3 years old group and 4-5 years old group,the children are in the rapid growth and development stage,and these two age groups can be used as the key observation indicators for the development of young children.The anterior-posterior diameter,longitudinal diameter,area of the pons and total brainstem area are strongly correlated with age,which can be used as the key observation indicators for the brainstem development in young children.

关 键 词：脑干 径线 面积 夹角 MRI 形态学发育特征 幼童 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R651