靶向抑制NLRP3炎性小体在脊髓损伤中的研究进展  

Research progress of targeted inhibition of NLRP3 inflammasome in spinal cord injury

作　　者：朱晶惠 魏栋敏 任淑婷 杨彦玲[1] 赵琳[1] ZHU Jinghui;WEI Dongmin;REN Shuting;YANG Yanling;ZHAO Lin(Medical College of Yan'an University,Yan'an 716000,China)

机构地区：[1]延安大学医学院,716000

出　　处：《天津医药》2023年第7期781-784,共4页Tianjin Medical Journal

基　　金：国家自然科学基金资助项目(81641048,81760235);陕西省科技厅社会发展领域项目(2021SF-082)。

摘　　要：脊髓损伤(SCI)是一种难以治愈的神经创伤性疾病,常见病因包括高空坠落、交通事故和重物砸伤等。炎症反应是机体在遭遇外界刺激时产生的免疫保护防线,适当的炎症反应可保护机体免受内外源性侵害。核苷酸结合寡聚结构域样受体蛋白3(NLRP3)炎性小体作为目前研究最多的炎性小体,研究发现其在SCI后表达量显著增加,并介导炎症级联反应。该文就NLRP3的激活机制及脊髓损伤后靶向抑制NLRP3激活机制的相关措施进行综述。Spinal cord injury(SCI)is a neurotraumatic disease that is difficult to cure,and common causes include falling from height,traffic accident and heavy object injury.Inflammatory response is an immune protection produced by body in response to external stimuli.Appropriate inflammatory response can protect body from endogenous and external damage.The nucleotide-binding domain-like receptor protein 3(NLRP3)inflammasome,as the most studied inflamolosome,has significantly increased expression after SCI and mediates the inflammatory cascade.This article reviews the activation mechanism of NLRP3 and relevant measures to inhibit the activation mechanism of NLRP3 after SCI.

关 键 词：脊髓损伤 NLR家族 热蛋白结构域包含蛋白3 炎症 

分 类 号：R322.8[医药卫生—人体解剖和组织胚胎学]