糖皮质激素联合环磷酰胺治疗肾病综合征的临床分析  

Clinical Analysis of Glucocorticoid Combined with Cyclophosphamide in the Treatment of Nephrotic Syndrome

作　　者：刘红丽 吴锡信[1] LIU Hongli;WU Xixin(Department of Nephrology,the Second People′s Hospital of Guangdong Province,Guangzhou,Guangdong Province,510317 China)

机构地区：[1]广东省第二人民医院肾内科,广东广州510317

出　　处：《系统医学》2023年第6期98-101,共4页Systems Medicine

摘　　要：目的探索糖皮质激素联合环磷酰胺治疗肾病综合征患者的临床价值及对肾功能恢复的影响。方法选取2018年8月—2022年9月广东省第二人民医院肾内科收治的120例肾病综合征患者为研究对象,采用随机数表法分为两组,各60例。对照组采取基础治疗联合糖皮质激素,观察组则在对照组用药方案的基础上增加环磷酰胺。观察两组临床疗效、肾功能指标、不良反应发生率以及生活质量评分。结果观察组的总有效率93.33%高于对照组的80.00%,差异有统计学意义(χ^(2)=4.615,P<0.05)。治疗后,观察组血肌酐及血清白蛋白水平高于对照组,尿素氮及24 h尿蛋白定量水平低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗后,观察组生存质量得分优于对照组,差异有统计学意义(P<0.05)。结论糖皮质激素联合环磷酰胺可以进一步提高治疗效果,改善肾功能,优化血清学指标,提高患者生存质量,且用药安全性良好。Objective To explore the clinical value of glucocorticoids combined with cyclophosphamide in the treatment of nephrotic syndrome patients and its impact on renal function recovery.Methods 120 patients with nephrotic syndrome admitted to the Department of Nephrology at Guangdong Second People′s Hospital from August 2018 to September 2022 were selected as the study subjects.They were randomly divided into two groups using a random number table method,with 60 patients in each group.The control group received basic treatment combined with glucocorticoids,while the observation group received cyclophosphamide in addition to the control group′s medication regimen.Observed the clinical efficacy,renal function indicators,incidence of adverse reactions,and quality of life scores of two groups.Results The total effective rate of the observation group was 93.33%higher than 80.00%of the control group,the difference was statistically significant(χ^(2 )=4.615,P<0.05).After treatment,the levels of serum creatinine and albumin in the observation group were higher than those in the control group,while the levels of urea nitrogen and 24-hour urine protein in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the quality of life score of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of glucocorticoids and cyclophosphamide can further improve treatment efficacy,improve renal function,optimize serological indicators,improve patient quality of life,and have good medication safety.

关 键 词：肾病综合征 糖皮质激素 环磷酰胺 肾功能 不良反应 

分 类 号：R692.6[医药卫生—泌尿科学]