慢性阻塞性肺疾病生物学标志物的研究进展  

Research progress on biomarkers of chronic obstructive pulmonary diseases

作　　者：肖心儒 施宇佳 张倩 XIAO Xinru;SHI Yujia;ZHANG Qian(Department of Respiratory and Critical Care Medicine,Affiliated Changzhou NO.2 People’s Hospital of Nanjing Medical University,Changzhou 213003,China)

机构地区：[1]南京医科大学附属常州第二人民医院呼吸与危重症医学科,江苏常州213003

出　　处：《南京医科大学学报（自然科学版）》2023年第7期1011-1016,1021,共7页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省社会发展项目(BE2020651);江苏省第五期“333”高层次人才项目(BRA2020015);常州市科技项目(CE20205023);常州市卫健委青年人才科技项目(WZ202010)。

摘　　要：慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是以气流受限为主要特征的一类疾病,与吸入香烟、烟雾等有害气体或有害颗粒引起的复杂病理改变有关,包括大、小气道的炎症和肺实质的破坏。COPD的发病机制尚未十分明确,目前认为与气道炎症、免疫因素、氧化应激、蛋白酶及抗蛋白酶失衡等机制有关。与COPD发病机制密切相关的分子生物学标志物在疾病发生发展过程中发挥着重要作用,文章对不同发病机制对应的分子生物学标志物进行综述。Chronic obstructive pulmonary diseases(COPD)is a kind of disease characterized by airflow restriction.It is related to complex pathological changes caused by inhalation of harmful gases or particles such as cigarettes and smoke,including inflammation of large and small airways and destruction of lung parenchyma.The pathogenesis of COPD is still unclear,and is currently believed to be related to airway inflammation,immune factors,oxidative stress,protease and antiprotease imbalance.Molecular biomarkers closely related to the pathogenesis of COPD play an important role in the occurrence and development of the disease.This paper reviewed the molecular biomarkers corresponding to different pathogenesis of COPD.

关 键 词：慢性阻塞性肺疾病 生物学标志物 

分 类 号：R563[医药卫生—呼吸系统]