阻塞性睡眠呼吸暂停综合征的脑血管反应性改变与醒后卒中的相关性研究进展  

Research progress on the correlation among the changes of cerebrovascular reactivity in OSAS and wake-up stroke

作　　者：李娇蓉 徐云瑀 赵智艳 张颖[1] 缪薇[1] LI Jiaorong;XU Yunyu;ZHAO Zhiyan;ZHANG Ying;SHANG Zhengfu;MIAO Wei(The Second Affiliated Hospital of Kunming Medical University,Kunming 650000,China)

机构地区：[1]昆明医科大学第二附属医院神经内科,650032

出　　处：《中国老年保健医学》2023年第3期94-99,共6页Chinese Journal of Geriatric Care

基　　金：中国醒后卒中多中心登记研究(编号:GN-2018R0008);云南省科技厅重点研发项目(编号:202203AC100007-2);昆明医科大学研究生创新基金(编号:2022S291)。

摘　　要：醒后卒中(WUS)是缺血性卒中的一种特殊类型,因为没有明确的发病时间,如何选择合适的治疗仍不清楚,患者往往错过最佳治疗时间。阻塞性睡眠呼吸暂停综合征(OSAS)为睡眠呼吸障碍性疾病,与缺血性卒中密切相关。阻塞性睡眠呼吸暂停综合征患者夜间低氧及二氧化碳水平波动导致脑血管反应性(CVR)损伤,卒中风险随着增高,但其与醒后卒中的关联性尚不清楚。因此,本文对阻塞性睡眠呼吸暂停综合征与醒后卒中的相关性及阻塞性睡眠呼吸暂停综合征的脑血管反应性改变及其机制进行综述,以期找到目前研究领域中可靠的证据。Wake-up stroke is a special type of ischemic stroke,because there is no clear onset time,how to choose the appropriate treatment is still unclear,the patient often miss the optimal treatment time.Obstructive sleep apnea syndrome is a sleep breathing disorder,which is closely related to ischemic stroke.Low oxygen and fluctuating carbon dioxide levels at night in patients with OSAS lead to cerebrovascular reactivity injury,and the risk of stroke increases,but the correlation between obstructive sleep apnea syndrome and wake-up stroke remains unclear.Therefore,this paper review the correlation between obstructive sleep apnea syndrome and wake-up stroke,as well as the changes in cerebrovascular reactivity of obstructive sleep apnea syndrome and its mechanism,in order to find reliable evidence in the current research field.

关 键 词：醒后卒中 阻塞性睡眠呼吸暂停综合征 脑血管反应性 

分 类 号：R766[医药卫生—耳鼻咽喉科] R743.3[医药卫生—临床医学]