细胞治疗遗传性大疱性表皮松解症研究进展  

Cell therapy for hereditary epidermolysis bullosa

作　　者：李越 吴金燕 袁若月 杨屈杨 赵贤省 朱宁文 Li Yue;Wu Jinyan;Yuan Ruoyue;Yang Quyang;Zhao Xiansheng;Zhu Ningwen(Department of Dermatology,Huashan Hospital,Fudan University,Shanghai 200040,China)

机构地区：[1]复旦大学附属华山医院皮肤科,上海200040

出　　处：《中华皮肤科杂志》2023年第7期698-702,共5页Chinese Journal of Dermatology

基　　金：中国科学院战略性先导科技专项(A类)(XDA16040400);上海市科研计划项目(19441909900)。

摘　　要：遗传性大疱性表皮松解症(EB)是一种罕见的残毁型、致死型单基因遗传性皮肤病,对社会和家庭造成了沉重负担。细胞疗法因其卓越稳定的临床疗效成为EB治疗中极有前景的一种手段,本文从干细胞和体细胞两方面总结近年来细胞疗法在EB的实验室研究及临床应用方面的进展。Hereditary epidermolysis bullosa(EB)is a rare mutilating and lethal inherited single-gene skin disease,and places a heavy burden on society and families.Cell therapy has become a very promising method for the treatment of EB due to its excellent and stable clinical efficacy.This review summarizes progress in laboratory research and clinical application of stem cell-and somatic cell-based therapies in EB in recent years.

关 键 词：大疱性表皮松解 组织治疗 干细胞 组织工程皮肤 单基因遗传性皮肤病 

分 类 号：R758.59[医药卫生—皮肤病学与性病学]