层层自组装薄膜改性的电化学传感器应用  

Research on the Applications of Electrochemical Sensor Modified with Layer-by-Layer Self-Assembly Films

作　　者：施高凡 林祥德 柳华杰[3] 张蒙蒙 夏鹏鹏 刘思思 陈玉竹 曾冬冬 Shi Gaofan;Lin Xiangde;Liu Huajie;Zhang Mengmeng;Xia Pengpeng;Liu Sisi;Chen Yuzhu;Zeng Dongdong(School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China;The Medical Instrumentation College,Shanghai University of Medicine&Health Sciences,Shanghai 201318,China;School of Chemical Science and Engineering,Tongji University,Shanghai 200092,China)

机构地区：[1]上海理工大学健康科学与工程学院,上海200093 [2]上海健康医学院医疗器械学院,上海201318 [3]同济大学化学科学与工程学院,上海200092

出　　处：《中国生物医学工程学报》2023年第3期370-384,共15页Chinese Journal of Biomedical Engineering

基　　金：上海市自然科学基金(19ZR1474300);上海健康医学院科研骨干校外导师制项目(2021-4);同济大学访问学者项目(2022)。

摘　　要：电化学传感器具有优异的灵敏度、检测限、选择性和响应速度,被广泛用于各种生物化学物质的检测。电极作为电化学传感器的敏感元件,合理的表面改性涂层对提高传感器的检测精度和稳定性尤为重要。层层自组装技术是通过在电极基底上交替沉积具有相互作用的物质,以纳米级精度构建参数可控的三维材料体系,在电化学传感器领域已得到广泛应用。综述了层层自组装技术的成膜材料(包括聚电解质和纳米颗粒等)、成膜作用力(包括静电作用、共价键、氢键等)及其性能优化与技术改进,并介绍了基于纳米材料构建改性的层层自组装薄膜电化学传感器,展示了其在生物标志物检测、空气监测和金属离子检测等方面的应用实例。Electrochemical sensors are widely used in the detection of various biochemical substances due to their excellent sensitivity,detection limit,selectivity and response rate.The electrode acts as a sensitive element of electrochemical sensors,and a reasonable surface modification coating is particularly important to improve the detection accuracy and stability of the sensor.The layer-by-layer self-assembly technology is widely used in the field of electrochemical sensors,because it is able to construct three-dimensional material system with nanometer precision controllable parameters by alternately depositing interacting substances on the substrate.In this paper,we summarized assembly materials(including polyelectrolytes and nanoparticles,etc.)the film driven force(including electrostatic interaction,covalent bond,hydrogen bond,etc.),performance optimization and technical improvement of the layer-by-layer self-assembly technologies were summarized.In addition,electrochemical sensors modified by layer-by-layer self-assembly films of nanomaterials and their applications in biomarker detection,air monitoring,metal ion detection were introduced.

关 键 词：层层自组装技术 电化学传感器 生物标志物 空气 金属离子 

分 类 号：R318[医药卫生—生物医学工程]