2019-2021年北京市丰台区手足口病及疱疹性咽峡炎病原学监测结果分析  

Analysis on monitoring results of etiology of HFMD and HA in Fengtai District of Beijing from 2019 to 2021

作　　者：曹佳琪 邢洪光[1] 张志敏 秦萌[1] 余红[1] 封会茹[1] 尉秀霞[1] 王兆娥[1] 颜涛 张玲[1] 张建军[1] CAO Jiaqi;XING Hongguang;ZHANG Zhimin;QIN Meng;YU Hong;FENG Huiru;WEI Xiuxia;WANG Zhaoe;YAN Tao;ZHANG Ling;ZHANG Jianjun(Fengtai District Center for Disease Control and Prevention,Beijing 100071,China)

机构地区：[1]北京市丰台区疾病预防控制中心,北京100071

出　　处：《寄生虫病与感染性疾病》2023年第2期95-99,103,共6页Parasitoses and Infectious Diseases

摘　　要：目的 探讨北京市丰台区手足口病和疱疹性咽峡炎病例中肠道病毒的感染情况,对其流行病学及病原学特征进行分析,为疾病的预防控制及临床治疗提供科学依据及相关指导。方法 收集2019-2021年北京市丰台区哨点医院常规监测及聚集疫情相关的手足口病及疱疹性咽峡炎病例样本,采用实时荧光PCR方法进行肠道病毒检测,使用SPSS 22.0软件进行统计分析,以P<0.05为差异有统计学意义。结果 共收集病例样本1 206份,其中手足口病样本814份,检出肠道病毒阳性563件,阳性率为69.16%,其中优势毒株为Cox A6(51.33%);疱疹性咽峡炎样本392份,阳性样本228件,阳性率为58.16%。手足口病和疱疹性咽峡炎的发病高峰期主要为夏秋季;发病年龄均以1~5岁儿童为主,占比分别为77.15%和81.38%;男性发病均高于女性,比例分别为1.46∶1和1.02∶1。结论 近年来手足口病及疱疹性咽峡炎的流行血清型发生改变,以Cox A6为主;夏秋季应加强对托幼儿童手足口病及疱疹性咽峡炎的监测及防控;进一步加强对手足口病及疱疹性咽峡炎的关联性研究。Objective To investigate the infection of enterovirus in cases of hand,foot and mouth disease(HFMD)and herpangina(HA)in Fengtai District of Beijing,and to analyze its epidemiological and etiological characteristics,so that to provide scientific basis and relevant guidance for disease prevention,control and clinical treatment.Methods Samples of HFMD cases,HA cases and epidemic cases associated with routine surveillance and clusters in sentinel hospitals of Fengtai District in Beijing from 2019 to 2021 were collected.The real-time fluorescence-PCR was used to detect the enterovirus,SPSS 22.0 was used for statistical analysis,and the difference P<0.05 was considered statistically significant.Results A total 1206 samples were collected,814 cases were HFMD.The positive rate of enterovirus was 69.16%,and the dominant strain was Cox A6(51.33%).Among 392 HA cases,228were positive,with the positive rate of 58.16%.The incidence peaks of HFMD disease and HA were mainly in summer and autumn.The age of onset was mainly in children aged 1 to 5 years old,accounting for 77.15%(HFMD)and 81.38%(HA),respectively.The incidence rate of male was higher than that of female,with ratios of 1.46:1 and 1.02:1,respectively.Conclusions In recent years,the prevalent serotypes of HFMD and HA have changed,and gradually changed to Cox A6.In summer and autumn,the prevention and control in children aged 1-6 should be strengthened and the research on the relationship between HFMD and HA should be further strengthened.

关 键 词：肠道病毒 手足口病 疱疹性咽峡炎 病原学监测 

分 类 号：R725.1[医药卫生—儿科] R766.12[医药卫生—临床医学] R181.3