动物细胞培养基质片状载体的研究及应用进展  

Advances in research and application of animal cell culture matrix fibracel carriers

作　　者：马春英(综述) 王美皓(综述) 马忠仁(审校)[2,4] 王家敏(审校)[2,4] MA Chunying;WANG Meihao;MA Zhongren;WANG Jiamin(Life Science and Engineering College of Northwest Minzu University,Lanzhou 730030,Gansu Province,China;不详)

机构地区：[1]西北民族大学生命科学与工程学院,甘肃兰州730030 [2]西北民族大学生物医学研究中心甘肃省动物细胞技术创新中心,甘肃兰州730030 [3]甘肃省生物工程材料工程研究中心,甘肃兰州730010 [4]西北民族大学生物工程与技术国家民委重点实验室,甘肃兰州730030

出　　处：《中国生物制品学杂志》2023年第6期731-736,741,共7页Chinese Journal of Biologicals

基　　金：中央高校基本科研业务费专项资金(31920210053,31920-220022);国家重大科技专项(2015ZX09102016)。

摘　　要：以聚酯纤维为基质的片状载体具有良好的耐酸碱性、耐热性、生物相容性以及不可生物降解、促进细胞黏附和生长等优点。片状载体无动物源性成分,生物安全性高,是细胞培养基质的首选载体之一。近年来,随着生物技术的发展,广泛应用于细胞基质生物制品等研发及生产中。本文对片状载体的结构和细胞培养特点以及在疫苗生产、细胞治疗和组织工程等中的应用作一综述,为片状载体技术后续的进一步研发和应用提供理论依据。Fibracel carriers based on polyester fiber have the advantages of good acid and alkali resistance,heat resistance,good biocompatibility,non-biodegradation,and can promote cell adhesion and growth.With no animal-derived ingredients and high biological safety,it is one of the preferred carriers for cell culture matrixes,which has been widely used in the development and production of cell matrix biological products with the development of biotechnology in recent years.This paper reviewed the structure and cell culture characteristics of fibracel carriers as well as the applications in vaccine production,cell therapy and tissue engineering,so as to provide a theoretical basis for the further development and application of fibracel carrier technology.

关 键 词：片状载体 纤维载体 生物反应器 

分 类 号：Q813.1[生物学—生物工程]