细菌鞭毛蛋白作为疫苗佐剂应用的研究进展  

Research progress of bacterial flagellin as a vaccine adjuvant

作　　者：项婷婷(综述) 马淑敏(综述) 沃恩康(审校) XIANG Tingting;MA Shumin;WO Enkang(School of Laboratory Medicine and Bioengineering,Hangzhou Medical College,Hangzhou 310013,ZhejiangProvince,China)

机构地区：[1]杭州医学院检验医学院生物工程学院,浙江杭州310013

出　　处：《中国生物制品学杂志》2023年第6期764-768,共5页Chinese Journal of Biologicals

基　　金：浙江省自然科学基金(LY18H100005);浙江省医药卫生科技计划项目(2021KY637,2021KY636,2020KY098)。

摘　　要：疫苗在传染性疾病预防控制中发挥重要作用。细菌鞭毛蛋白能激活宿主细胞Toll样受体5(Toll like receptor 5,TLR5)和NOD样受体C4(NOD like receptor C4,NLRC4),具有免疫佐剂效应。作为新型免疫佐剂,鞭毛蛋白既能与抗原蛋白共同作用,又能与抗原蛋白融合表达,均能显著提高免疫效果;同时,其在黏膜免疫和抗肿瘤免疫中也取得较好的应用效果,成为疫苗佐剂研发的热点。本文主要就细菌鞭毛蛋白作为疫苗佐剂应用的研究进展作一综述,以期为鞭毛蛋白佐剂疫苗的研发提供新思路。Vaccines play an important role in the prevention and control of infectious diseases.Bacterial flagellin can activate Toll like receptor 5(TLR5)and NOD like receptor C4(NLRC4)in host cells,and has immune adjuvant effect.As a new immune adjuvant,flagellin can not only share with antigen protein,but also fuse with antigen protein,which can significantly improve the immune effect.At the same time,it has achieved good application effect in mucosal immunity and antitumor immunity,becoming a hot spot in the research and development of vaccine adjuvants.This review mainly discussed the research progress on application of bacterial flagellin as vaccine adjuvant,so as to provide new ideas for the development of flagellin adjuvant vaccine.

关 键 词：鞭毛蛋白 佐剂 疫苗 细菌 融合蛋白 

分 类 号：R34[医药卫生—基础医学]