多巴胺基水下粘合剂在生物医学领域的研究进展  

Research Progress of Dopamine-based Underwater Adhesives in Biomedical Field

作　　者：丁佳强 齐利 吴锦秋 陈栋梁[1] 熊成东[1] 熊左春[1] DING Jia-qiang;QI Li;WU Jin-qiu;CHEN Dong-liang;XIONG Cheng-dong;XIONG Zuo-chun(Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu 610041,China;University of Chinese Academy of Sciences,Beijing 101400,China;Food and Drug Inspection Center of Anyang City,Anyang 455000,China)

机构地区：[1]中国科学院成都有机化学研究所,成都610041 [2]中国科学院大学,北京101400 [3]安阳市食品药品检验检测中心,安阳455000

出　　处：《高分子通报》2023年第7期794-805,共12页Polymer Bulletin

摘　　要：面对体内的复杂环境,传统医用粘合剂缺乏优异的组织粘附性能。贻贝启发的粘合剂凭借优异的水下粘附能力,在生物医用领域的应用备受关注。多巴胺与贻贝蛋白中的邻苯二酚具有相似的结构和性能,通过引入多巴胺而制备的粘合剂被广泛研究。首先,多巴胺基粘合剂中的高活性酚羟基凭借共价或非共价的相互作用,在生物组织表面可以实现稳定粘附;其次,高活性酚羟基还可以赋予粘合剂优越的细胞亲和力和细胞粘附性。多巴胺基粘合剂可以实现在水环境下粘附性能的保持,并且具有生物相容性、细胞粘附性等特性。由此可见,多巴胺的引入为组织粘合剂提供了更加广阔的空间和巨大的发展潜力。本文综述了多巴胺基粘合剂在生物医学领域的最新研究进展。根据引入多巴胺的方式,从超支化聚合物的功能化和线形聚合功能性小分子两个方向分析其结构设计、粘附强度的影响因素;最后讨论了多巴胺基粘合剂目前存在的问题以及未来的发展前景。Facing complex internal environment in human body,traditional medical adhesives have bad performance in binding tissues.Mussel-inspired adhesives have excellent underwater adhesion capability,which has arisen much attention on the application of such type of adhesives in the field of biomedical materials.Because dopamine has a similar structure and properties to the catechol in mussel protein,adhesives based on dopamine have been investigated widely.Firstly,the highly active phenolic hydroxyl groups in dopamine-based adhesives can adhere stably to the surface of tissues through covalent or non-covalent interactions.Secondly,the highly active phenolic hydroxyl group can also give adhesives superior cell affinity and cell adhesion.Dopamine-based adhesives can maintain the adhesion property underwater and have the characteristics of biocompatibility and cell adhesion.It can be seen that the addition of dopamine provides a larger room for developing tissue adhesives.This paper reviews the latest research progress of dopamine-based adhesives in the field of biomedical materials.According to the different ways of adding dopamine,the influencing factors of their adhesion strength and structure design are analyzed from two directions:functional hyperbranched polymer and linear polymerization of small molecules.Finally,existing problems and future development of dopamine-based adhesives are discussed.

关 键 词：贻贝 多巴胺 生物粘合剂 结构设计 粘附性能 

分 类 号：R318[医药卫生—生物医学工程]