黄体酮注射液致注射部位异物肉芽肿  

Foreign body granuloma at the injection site caused by progesterone injection

作　　者：甘继美 韩晓军[2] 黄瑶[3] 徐国强 杨巧 Gan Jimei;Han Xiaojun;Huang Yao;Xu Guoqiang;Yang Qiao(Department of Pharmacy,Wenjiang District People′s Hospital of Chengdu,Chengdu 611130,China;Thyroid and Breast Surgery,Wenjiang District People′s Hospital of Chengdu,Chengdu 611130,China;Department of Pathology,Wenjiang District People′s Hospital of Chengdu,Chengdu 611130,China)

机构地区：[1]成都市温江区人民医院药学部,成都611130 [2]成都市温江区人民医院甲状腺乳腺外科,成都611130 [3]成都市温江区人民医院病理科,成都611130

出　　处：《药物不良反应杂志》2023年第6期376-378,共3页Adverse Drug Reactions Journal

基　　金：成都市医学科研课题(2021026)。

摘　　要：1例31岁女性患者无意中发现右侧臀部皮下有胡豆大小的包块,按压微痛。臀部超声检查示右侧臀部皮下脂肪层多个大小不等的囊性结节。患者行右侧臀部包块切除术,根据术后病理及病史,诊断为异物肉芽肿。5年前患者曾因先兆流产予以双侧臀部肌内注射黄体酮(10~15 mg、1次/d)3个月,之后臀部未再注射过其他药物。因此考虑臀部异物肉芽肿与该部位注射黄体酮有关。2个月后患者再次行左侧臀部臀大肌下软组织肿物扩大切除术,术后病理结果与第1次相同。A 31‑year‑old female patient accidentally found a bean‑sized lump under the right buttock,causing slight pain when pressing.Ultrasound examination revealed multiple cystic nodules of varying sizes in the subcutaneous fat layer of the right buttock.The patient underwent right buttock mass resection and was diagnosed as foreign body granuloma according to the postoperative pathology and medical history.Five years ago,the patient received bilateral intramuscular injection of progesterone(10‑15 mg once daily)into the buttocks for 3 months due to threatened miscarriage.Afterwards,no other medication was injected into the buttocks.Therefore,it was considered that the foreign body granuloma in her buttock was related to the injection of progesterone.Two months later,the patient underwent extended resection of soft tissue tumor under the gluteus maximus muscle of the left buttock,and the postoperative pathological results were the same as that of the first time.

关 键 词：黄体酮 肉芽肿 异物 

分 类 号：R969[医药卫生—药理学]