峰值应变离散度是评价糖尿病患者左室收缩功能变化的可靠性指标  

Peak strain dispersion is a reliable index for evaluating left ventricular systolic function in diabetic patients

作　　者：杨倩 张霞 马强 汤敏 YANG Qian;ZHANG Xia;MA Qiang;TANG Min(Department of Ultrasound Medical,The First Affiliated Hospital of Wannan Medical Colledge,Wuhu 241002,China)

机构地区：[1]皖南医学院第一附属医院超声医学科,安徽芜湖241002

出　　处：《分子影像学杂志》2023年第4期643-647,共5页Journal of Molecular Imaging

基　　金：安徽省公益性技术应用研究联动计划项目(1704f0804048);芜湖市科技计划项目(2020ms3-5)。

摘　　要：目的应用峰值应变离散度(PSD)对2型糖尿病患者左室收缩功能的早期改变进行探索。方法收集本院2型糖尿病患者95例,根据糖化血红蛋白进一步分组,分为血糖控制组(A组,糖化血红蛋白<7%,n=45)和血糖未控制组(B组,糖化血红蛋白≥7.0%,n=50),另取健康体检者50例作为对照组。所有参与者均行常规超声心动图检查并取其参数,采集连续3个心动周期的左室心尖二腔、三腔、四腔。存储二维动态图像在后台描记分析,获得左室整体纵向应变及PSD。比较3组之间参数的差异。结果A组与对照组间整体纵向应变的差异无统计学意义(P=0.08),B组与对照组相比整体纵向应变减小(P<0.01)。A组及B组与对照组相比,PSD均明显增高(P<0.01)。相关性分析显示,左室整体纵向应变与PSD间呈负相关关系,糖化血红蛋白及空腹血糖与左室PSD呈正相关关系(P<0.01)。结论PSD可定量评价2型糖尿病患者早期左室收缩功能的改变,是评定糖尿病患者左室心肌运动的一个早期、可靠的指标。Objective To investigate the early changes of left ventricular systolic function in patients with type 2 diabetes mellitus using peak strain dispersion(PSD).Methods Ninety-five patients with type 2 diabetes mellitus were enrolled.They were divided into two groups based on their HbA1c levels:controlled blood glucose group(group A,HbA1c<7%,n=45)and uncontrolled blood glucose group(group B,HbA1c≥7.0%,n=50).An additional 50 healthy subjects were selected as control group.Conventional echocardiography was performed,and parameters were obtained.The left ventricular global longitudinal strain and PSD were obtained using two-dimensional dynamic images and tracing analysis.The differences in parameters between the groups were compared.Results There was no significant difference in left ventricular global longitudinal strain between group A and the control group(P=0.08),while left ventricular global longitudinal strain in group B was significantly reduced compared with the control group(P<0.01).Compared with the control group,PSD was significantly increased in group A and group B(P<0.01).Correlation analysis revealed that left ventricular global longitudinal strain was negatively correlated with PSD,while glycosylated hemoglobin and fasting blood glucose were positively correlated with PSD(P<0.01).Conclusion PSD can be used to quantitatively evaluate changes in left ventricular systolic function in patients with type 2 diabetes mellitus.PSD is an early and reliable indicator for evaluating left ventricular myocardial movement in patients with diabetes.

关 键 词：2型糖尿病 整体纵向应变 峰值应变离散度 超声心动描记术 心室功能 

分 类 号：R445.2[医药卫生—影像医学与核医学] R587.1[医药卫生—诊断学]