CT值联合凝血纤溶相关指标对下肢深静脉血栓发生的诊断价值  

Analysis of the diagnostic value of CT value combined with coagulation and fibrinolysis related indexes in the occurrence of deep vein thrombosis of lower extremity

作　　者：陶蜀杭 王远军 何海 TAO Shuhang;WANG Yuanjun;HE Hai(Department of Laboratory,Chengdu Second People's Hospital,Chengdu 610017,China;Department of Imaging,Chengdu Second People's Hospital,Chengdu 610017,China)

机构地区：[1]成都市第二人民医院检验科,四川成都610017 [2]成都市第二人民医院影像科,四川成都610017

出　　处：《分子影像学杂志》2023年第4期701-705,共5页Journal of Molecular Imaging

基　　金：四川省卫生和计划生育科研课题(17PJ332)。

摘　　要：目的分析CT值联合凝血纤溶指标对下肢深静脉血栓(DTV)的诊断价值分析。方法选取2019年1月~2022年5月本院收治的发生下肢DTV的98例患者为研究组,另取同期本院未发生下肢DTV的98例患者为对照组。所有患者均进行CT检查和测定凝血纤溶指标[活化部分凝血酶原时间(aPTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)、D-二聚体(D-D)、抗凝血酶Ⅲ(ATⅢ)],采用Logistic回归分析CT值、凝血纤溶指标与下肢DTV的相关性,并采用ROC曲线分析CT值和凝血纤溶指标对下肢DTV的诊断价值,计算曲线下面积。结果CT图像显示,下肢DTV的静脉管腔未见造影剂填充,呈低密度;相较于对照组,研究组CT值、FIB、D-D均较高(P<0.05),aPTT、PT、ATⅢ均较低(P<0.05);Logistic回归结果显示,CT值、aPTT、PT、FIB、D-D、ATⅢ与下肢DTV存在显著相关性(P<0.05);ROC曲线结果显示,联合诊断的曲线下面积为0.946,敏感度为81.63%,特异性为95.92%。结论CT值、凝血纤溶指标与下肢DTV具有相关性,其联合诊断在下肢DTV患者方面具有较高的应用价值。Objective To analyze the diagnostic value of CT value combined with coagulation and fibrinolysis index in the diagnosis of lower extremity deep vein thrombosis(DTV).Methods A total of 98 patients with lower extremity DTV admitted to our hospital from January 2019 to May 2022 were selected as the research group,and 98 patients without lower extremity DTV in our hospital during the same period were selected as the control group.All patients underwent CT examination and determination of coagulation and fibrinolysis indexes[activated partial prothrombin time(aPTT),prothrombin time(PT),fibrinogen(FIB),D-dimer(D-D),antithrombinⅢ(ATⅢ)],Logistic regression was used to analyze the correlation between CT value,coagulation and fibrinolysis index and lower extremity DTV,and ROC curve was used to analyze the diagnostic value of CT values and coagulation and fibrinolysis indexes for lower extremity DTV,and the area under the curve was calculated.Results CT images showed that the venous lumen of DTV in lower limbs was not filled with contrast agent,showing low density;compared with the control group,the CT value,FIB,and D-D of the study group were significantly higher(P<0.05),aPTT,PT and ATⅢwere significantly lower(P<0.05);Logistic regression results showed that CT value,aPTT,PT,FIB,D-D,ATⅢwere significantly correlated with lower extremity DTV(P<0.05).ROC curve results showed that the area under the curve of the combined diagnosis was 0.946,the sensitivity was 81.63%,and the specificity was 95.92%.Conclusion CT value,coagulation and fibrinolysis index are correlated with lower extremity DTV,and their combined diagnosis has high application value in patients with lower extremity DTV.

关 键 词：CT值 凝血纤溶指标 下肢深静脉血栓 诊断价值 

分 类 号：R543.6[医药卫生—心血管疾病] R816.2[医药卫生—内科学]