右归丸治疗膝骨关节炎实验研究进展  

Experimental Research Progress of Yougui Pill in Treating Knee Osteoarthritis

作　　者：李万云 颜春鲁[1,2,3] 安方玉 汪斌[4] LI Wan-yun;YAN Chun-lu;AN Fang-yu;WANG Bin(Gansu University of Traditional Chinese Medicine,Lanzhou,Gansu 730000;Dunhuang Key Laboratory of the Ministry of Education,Lanzhou,Gansu730000;Key Laboratory of Molecular Medicine and TCM Prevention Research of Major Diseases in Gansu Province,Lanzhou,Gansu730000;Liangzhou Hospital,Wuwei City,Gansu Province,Wuwei,Gansu,733000)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]敦煌医学与转化省部共建教育部重点实验室,甘肃兰州730000 [3]甘肃省高校重大疾病分子医学与中医药防治研究重点实验室,甘肃兰州730000 [4]甘肃省武威市凉州医院,甘肃武威733000

出　　处：《按摩与康复医学》2023年第8期66-68,73,共4页Chinese Manipulation and Rehabilitation Medicine

基　　金：甘肃省高校重大疾病分子医学与中医药防治研究重点实验室开放基金资助项目(No.FZYX17-18-11);甘肃省中医药管理局科研项目(GZKP-2021-34)。

摘　　要：膝骨关节炎是一种由多种因素引起的以膝关节软骨退行性改变为主要特点的骨关节疾病,主要包括软骨细胞的凋亡、细胞外基质的降解以及炎性细胞因子的增多等病理变化。右归丸具有温肾补阳、益精填血之功效,大量动物实验研究表明,右归丸可以促进膝骨关节炎软骨细胞的增殖和抑制软骨细胞的凋亡,减少细胞外基质的降解,减少炎性细胞因子的活性,调控钙离子代谢,从而达到膝骨关节炎软骨修复的作用。现将近年来的实验研究成果进行综述。Knee osteoarthritis is a bone and joint disease caused by the degenerative changes of knee cartilage caused by various factors,mainly including the apoptosis of chondrocytes,the degradation of extracellular matrix and the increase of inflammatory cytokines.Right pill has the effect of warm kidney fill Yang,essence,a large number of animal experimental studies show that right pill can promote the proliferation of knee osteoarthritis chondrocytes and inhibit the apoptosis of chondrocytes,reduce the degradation of extracellular matrix,reduce the activity of inflammatory cytokines,regulate calcium ion metabolism,so as to achieve the role of knee osteoarthritis cartilage repair.The experimental research results in recent years are now reviewed.

关 键 词：膝骨性关节炎 右归丸 实验研究 综述 

分 类 号：R274.9[医药卫生—中西医结合]