人工静脉瓣膜周期变化中的力学性能研究  

Mechanical properties during periodical variation of prosthetic venous valve

作　　者：袁瑜含 谷雪莲[2] 崔建昆[1] 陶玉蓉 袁振宇 YUAN Yuhan;GU Xuelian;CUI Jiankun;TAO Yurong;YUAN Zhenyu(School of Mechanical Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China;School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China;Shanghai Bluevastec Medical Technology Co.,Ltd,Shanghai 201318,China)

机构地区：[1]上海理工大学机械工程学院,上海200093 [2]上海理工大学健康科学与工程学院,上海200093 [3]上海蓝脉医疗科技有限公司,上海201318

出　　处：《中国医学物理学杂志》2023年第7期917-924,共8页Chinese Journal of Medical Physics

基　　金：上海介入医疗器械工程技术研究中心资助项目(18DZ2250900)。

摘　　要：目的:研究各参数在人工静脉瓣膜周期变化中对力学性能的影响,为人工静脉瓣膜的设计与优化提供参考依据。方法:采用光滑粒子动力学方法进行双向流固耦合仿真,研究包含2种材料(膨化聚四氟乙烯和猪心包),3种长度(5.0、7.5和10.0 mm)和3种厚度(0.050、0.075和0.100 mm)的瓣膜共18组模型,通过对比张开孔径、最大等效应力及回流情况判断3个因素对瓣膜的影响。结果:瓣膜材料为猪心包时达到更大的张开孔径,最大值为5.90 mm,所受最大等效应力更平稳;在张开阶段当瓣膜长度为7.5 mm、厚度为0.100 mm时,最大等效应力值最小;在关闭阶段瓣膜材料为猪心包,瓣膜长度为10.0 mm、厚度为0.100 mm时,最大等效应力最小;瓣膜厚度为0.075 mm能获得最好的抗回流效果。结论:在一定范围内减小瓣膜长度和厚度,增加瓣膜材料的弹性模量,能增加人工静脉瓣膜周期运动的稳定性。Objective To investigate the effects of various parameters of prosthetic venous valve on its mechanical properties for providing reference for the design and optimization of prosthetic venous valve.Methods Smooth particle hydrodynamics method was used to evaluate the fluid-structure interaction between valve and blood.There were 18 groups of parameters,including 2 valve materials(ePTFE and porcine pericardium),3 valve lengths(5.0,7.5,10.0 mm)and 3 valve thicknesses(0.050,0.075,0.100 mm).The opening aperture,maximum equivalent stress and anti-reflux function were analyzed for determining the effects of the 3 factors on the valve.Results The valve made of porcine pericardium had a larger opening aperture,with a maximum of 5.90 mm,and the maximum equivalent stress on the valve was more stable.When the valve was opening,the maximum equivalent stress value on the valve with a length of 7.5 mm and a thickness of 0.100 mm was the lowest.When the valve was closing,the maximum equivalent stress on the valve with a length of 10.0 mm and a thickness of 0.100 mm was the lowest.A valve thickness of 0.075 mm was best for anti-reflux function.Conclusion Reducing the length and thickness of the valve within a certain range and increasing the elastic modulus of the valve material can increase the stability of prosthetic venous valve.

关 键 词：人工静脉瓣膜 力学性能 慢性静脉功能不全 有限元分析 

分 类 号：R318[医药卫生—生物医学工程]