调节性T细胞在弥漫大B细胞淋巴瘤肿瘤微环境的作用机制研究进展  

Research Progress on the Mechanism of Regulatory T Cells in Tumor Microenvironment of Diffuse Large B-cell Lymphoma

作　　者：何君 辜学忠[1,2] 林雅婷 李凡 HE Jun;GU Xuezhong;LIN Yating;LI Fan(Dept.of Hematology,The Affiliated Hospital of Kunming University of Science and Technology/The First People’s Hospital of Yunnan Province;Yunnan Provinccial Clinical Research Center for Hematologic Disease,Yunnan Province Clinical Center for Hematologic Diseases,Kunming Yunnan 650032,China)

机构地区：[1]云南省第一人民医院血液科/昆明理工大学附属医院血液内科 [2]云南省血液系统疾病临床医学研究中心/云南省血液疾病临床医学中心,云南昆明650032

出　　处：《昆明医科大学学报》2023年第6期150-154,共5页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(81860030);云南省基础研究计划-昆明医科大学应用基础研究联合专项基金资助项目[2018FE001(-113)];云南省临床医学中心开放项目(2020LCZXKF-XY02);云南省卫生健康委人才项目(D-2018018)。

摘　　要：弥漫大B细胞淋巴瘤是非霍奇金淋巴瘤中最常见的一种,目前CD20单克隆抗体联合化疗使其缓解率较前增加,但仍有部分人群疗效欠佳甚至耐药,仍需要开发新的药物提高缓解率。调节性T细胞作为免疫调节中发挥重要作用的细胞群体,其在弥漫大B细胞淋巴瘤肿瘤微环境中协调细胞和分子网络,介导局部免疫抑制状态,从而促进肿瘤细胞的增殖、迁移。据此有望靶向治疗弥漫大B细胞淋巴瘤。将对调节性T细胞在弥漫大B细胞淋巴瘤肿瘤微环境的作用机制作一综述。Diffuse large B-cell lymphoma is the most common type of non-Hodgkin lymphoma.At present,CD20 monoclonal antibody combined with chemotherapy has increased the response rate.However,some people still have poor efficacy or even drug resistance,and new drugs are still needed to improve the response rate.Regulatory T cells play an important role in immune regulation via coordinating cellular and molecular networks in tumor microenvironment in diffuse large B-cell lymphoma,and mediating local immunosuppression,consequently promoting tumor cell proliferation and migration.Therefore,it is promising to target the treatment of diffuse large Bcell lymphoma.This article reviews the mechanisms of regulatory T cells in the diffuse large B-cell lymphoma microenvironment.

关 键 词：弥漫大B细胞淋巴瘤 调节性T细胞 肿瘤微环境 

分 类 号：R551.2[医药卫生—血液循环系统疾病]