妊娠期糖尿病病人血清胱抑素C、糖化血红蛋白水平与胎儿心功能的关系  

Relationship between serum CysC and HbA1c levels and fetal cardiac function in patients with gestational diabetes mellitus

作　　者：连立芬 刘晓娟 LIAN Lifen;LIU Xiaojuan(Department of Obstetrics and Gynecology,Qinhuangdao Maternal and Child Health Hospital,Qinhuangdao,Hebei 066000,China)

机构地区：[1]秦皇岛市妇幼保健院妇产科,河北秦皇岛066000

出　　处：《安徽医药》2023年第8期1668-1671,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨妊娠期糖尿病(GDM)病人血清胱抑素C(Cys-C)、糖化血红蛋白(HbA1c)水平与胎儿心功能的关系,以期为临床及早判断GDM病人胎儿心功能异常提供参考。方法选取2018年12月至2020年1月河北省秦皇岛市妇幼保健院诊治的GDM孕妇75例为GDM组,并纳入同期体检健康孕妇75例为对照组。比较两组一般资料及血清Cys-C、HbA1c水平;测定胎儿(孕24~28周)心功能参数等容舒张时间(IRT)、射血时间(ET)、等容收缩时间(ICT),计算心肌做功指数(MPI);Pearson法分析GDM病人血清Cys-C、HbA1c水平与ICT、ET、IRT、MPI,及血清Cys-C水平与HbA1c的相关性。结果GDM组病人血清Cys-C[(1.71±0.57)mg/L比(0.53±0.18)mg/L]、HbA1c水平[(9.73±3.24)%比(5.47±1.82)%]及胎儿ICT[(43.14±9.53)ms比(39.72±8.75)ms]、IRT[(44.82±6.62)ms比(41.13±6.09)ms]、MPI水平(0.55±0.11比0.50±0.10)均高于对照组,差异有统计学意义(P<0.05);GDM病人血清Cys-C、HbA1c水平与MPI均呈正相关(r=0.49、0.54,P<0.05),血清Cys-C水平与HbA1c呈正相关(r=0.58,P<0.05)。结论CysC、HbA1c在GDM病人血清中呈高水平,二者均与MPI呈正相关,临床及时监测GDM病人血清Cys-C、HbA1c水平,有助于预防GDM病人胎儿的心功能异常。Objective To investigate the relationship between serum cystatin C(Cys-C),glycosylated hemoglobin(HbA1c)level and fetal cardiac function in patients with gestational diabetes mellitus(GDM),in order to provide reference for early clinical judgment of fetal cardiac function abnormalities in GDM patients.Methods Seventy-five pregnant women with GDM diagnosed and treated in Qinhuangdao Maternal and Child Health Hospital of Hebei Province from December 2018 to January 2020 were randomly selected as the GDM group,and 75 healthy pregnant women were included as the control group.The general data and serum Cys-C and HbA1c levels of GDM group and control group were compared;the fetal(24-28 weeks of pregnancy)cardiac function parameters such as isovolumic diastolic time(IRT),ejection time(ET)and isovolumic systolic time(ICT)were measured,and the myocardial work index(MPI)was calculated;Pearson method was used to analyze the correlation between serum Cys-C and HbA1c levels and ICT,ET,IRT,MPI,and serum Cys-C level and HbA1c in patients with GDM.Results The levels of serum Cys-C[(1.71±0.57)mg/L vs.(0.53±0.18)mg/L]and HbA1c[(9.73±3.24)%vs.(5.47±1.82)%]and fetal ICT[(43.14±9.53)ms vs.(39.72±8.75)ms],IRT[(44.82±6.62)ms vs.(41.13±6.09)ms]and MPI(0.55±0.11 vs.0.50±0.10)in GDM group were higher than those in control group,and the differences were statistically significant(P<0.05);the levels of serum Cys-C and HbA1c were positively correlated with MPI(r=0.49,0.54,P<0.05),and the levels of serum Cys-C were positively correlated with HbA1c(r=0.58,P<0.05).Conclusion CysC and HbA1c are at high levels in the serum of GDM patients,and both of them are positively correlated with MPI.Timely clinical monitoring of serum Cys-C and HbA1c levels in GDM patients is helpful to prevent fetal cardiac dysfunction in GDM patients.

关 键 词：糖尿病 妊娠 糖化血红蛋白 胎儿 胱抑素C 心功能 

分 类 号：R714.256[医药卫生—妇产科学]