2,2-二甲基丙二酸二甲酯的合成  

SYNTHESIS OF DIMETHYL 2,2-DIMETHYLMALONATE

作　　者：丁成荣[1] 吴坤 游兆镭 韩哲 殷燕龙 张国富[1] Ding Chengrong;Wu Kun;You Zhaolei;Han Zhe;Yin Yanlong;Zhang Guofu(College of Chemical Engineering,Zhejiang University of Technology,Hangzhou 310014,Zhejiang,China)

机构地区：[1]浙江工业大学化学工程学院,浙江杭州310014

出　　处：《精细石油化工》2023年第4期53-56,共4页Speciality Petrochemicals

摘　　要：以丙二酸二甲酯为起始原料,在甲醇钠的作用下与溴甲烷经甲基化反应合成2,2-二甲基丙二酸二甲酯,并对合成工艺进行优化。适宜工艺条件为:n(丙二酸二甲酯)∶n(溴甲烷)∶n(甲醇钠)=1.0∶2.8∶2.8,使用现制的甲醇钠,在回流温度下反应8 h合成2,2-二甲基丙二酸二甲酯,收率90.1%,含量99.3%。Dimethyl malonic acid was synthesized from dimethyl malonate by methylation reaction with methyl bromide and sodium methoxide as base,and the synthesis process was optimized.The optimized reaction conditions were as follows:the molar ratio of dimethyl malonate to sodium methoxide and methyl bromide is 1.0∶2.8∶2.8,and the freshly prepared sodium methoxide was used as base,the dimethyl dimethylmalonate was synthesized under reflux for 8 h.The product yield is 90.1%,and the purity is 99.3%.The new process has the advantages of simple synthesis route,high yield,good economic and practical value.

关 键 词：丙二酸二甲酯 溴甲烷 2 2-二甲基丙二酸二甲酯 甲醇钠 

分 类 号：TQ225[化学工程—有机化工]