身体质量指数与复发性流产患者胚胎非整倍体的相关性  

Analysis of body mass index and embryonic aneuploidy in patients with recurrent spontaneous abortion

作　　者：汪诗羽 王超[1] 韩丹[1] 张文香[1] 陈大蔚[1] 章志国[1] 曹云霞[1] 周平[1] WANG Shiyu;WANG Chao;HAN Dan;ZHANG Wenxiang;CHEN Dawei;ZHANG Zhiguo;CAO Yunxia;ZHOU Ping(Department of Obstetrics&Gynecology,the First Affiliated Hospital of Anhui Medical University,Hefei 230000,China)

机构地区：[1]安徽医科大学第一附属医院妇产科生殖中心,安徽合肥230000

出　　处：《安徽医学》2023年第7期753-756,共4页Anhui Medical Journal

基　　金：国家卫生健康委员会专项课题基金(编号:NHC-RMC-2021-2)。

摘　　要：目的探讨身体质量指数(BMI)对复发性流产(RSA)患者行胚胎植入前非整倍体遗传学检测(PGT-A)助孕结局的影响。方法回顾性分析2019年1月至2020年12月安徽医科大学第一附属医院因复发性流产行PGT-A助孕的187例患者临床资料。根据患者BMI分为低体质量组(n=10)、正常体质量组(n=135)和超重组(n=42)。比较3组实验室指标[获卵数、二原核卵裂数、总促性腺激素(Gn)天数、非整倍体胚胎率及无可移植胚胎率]、胚胎移植结局[临床妊娠率、流产率及活产率]差异。结果3组患者获卵数、二原核卵裂数、总Gn天数、非整倍体胚胎率及无可移植胚胎率比较,差异均无统计学意义(F=1.819、2.012、2.467,χ^(2)=0.924、0.040,P均>0.05)。在首次移植一枚整倍体胚胎后,超重组患者临床妊娠率和活产率低于正常体质量组,差异有统计学意义(χ^(2)=5.934、9.977,P<0.05);3组患者流产率比较,差异无统计学意义(χ^(2)=4.755,P>0.05)。结论BMI的增加并未导致RSA患者的胚胎非整倍体率增加,但会降低患者临床妊娠率及活产率。Objective To investigate the effect of body mass index(BMI)on the pregnancy outcome of preimplantation aneuploidy ge-netic test(PGT-A)in patients with recurrent spontaneousabortion(RSA).Methods The clinical data of 187 patients who underwent PGT-A due to recurrent abortion in the First Affiliated Hospital of Anhui Medical University from January 2019 to December 2020 were analyzed retro-spectively.The patients were divided into low body mass index group(n=10),normalbody mass index group(n=135)and overweight group(n=42)according to their BMI.The laboratory indicators of different BMI patients were compared,including(number of oocytes obtained,number of two pronucleicleavage,total gonadotropin(Gn)days,aneuploid embryo rate and non-transferable embryo rate),and embryo transfer outcome(clinical pregnancy rate,flow rate and live rate)were compared among the three groups.Results There was no significant difference in the number of oocytes obtained,the number of two pronucleicleavage,the total number of Gn days,the rate of aneuploid embryos and the rate of non-transferable embryos among the three groups(F=1.819、2.012、2.467,χ^(2)=0.924,0.040,P>0.05).After the first transfer of an aneuploid embryo,the clinical pregnancy rate and live birth rate of the overweight patients were lower than those of the normal body mass index patients(χ^(2)=5.934、9.977,P<0.05);there was no significant difference in the abortion rate among the three groups(χ^(2)=4.755,P>0.05).Conclusions The increase of body mass index does not lead to the increase of aneuploid embryo rate in patients with recurrent abortion,but may reduce the clinical pregnancy rate and live birth rate of patients.

关 键 词：身体质量指数 肥胖 复发性流产 非整倍体 

分 类 号：R71[医药卫生—妇产科学]